Recent Submissions

  • Exploring genetic outcomes as frailty biomakers 

    Valdiglesias, Vanessa; Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Pásaro, Eduardo; Laffon, Blanca (Oxford, 2018-04-19)
    [Abstract] Frailty has emerged as a reliable measure of the aging process. Because the early detection of frailty is crucial to prevent or even revert it, the use of biomarkers would allow an earlier and more objective ...
  • Frailty in older adults Is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations 

    Marcos-Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Gostner, Johanna M.; Fuchs, Dietmar; Pasaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Frontiers, 2018-05-16)
    [Abstract] Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related ...
  • Cognitive frailty: a conceptual systematic review and an operational proposal for future research 

    Facal, David; Maseda, Ana; Pereiro Rozas, Arturo; Gandoy-Crego, Manuel; Lorenzo-López, Laura; Yanguas, Javier; Millán-Calenti, José Carlos (Elsevier, 2018-12-07)
    [Abstract] Objective. To analyze the definition of “cognitive frailty” and to study the conceptual and operational definitions used and their implications for empirical research. The relationships between this concept and ...
  • Changes in frailty status in a community-dwelling cohort of older adults: the VERISAÚDE study 

    Lorenzo-López, Laura; López-López, Rocío; Maseda, Ana; Buján, Ana; Rodríguez-Villamil, José Luis; Millán-Calenti, José Carlos (Elsevier, 2018-11-15)
    [Abstract] Objectives: Greater understanding of changes in the degree of frailty is important for clarifying the natural history of frailty and may help clinical decision-making regarding preventive interventions. The ...
  • Frailty syndrome and genomic instability in older adults: suitability of the cytome micronucleus assay as a diagnostic tool 

    Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Bonassi, Stefano; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Oxford, 2018-01-13)
    [Abstract] Frailty, a condition involving increased risk of disability and mortality in older adults, has emerged as a reliable way to predict the effect of aging. Genomic instability may help to anticipate recognition of ...

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