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Relationship between DNA damage measured by the comet-assay and cognitive function
(Elsevier, 2022-10-17)
[Abstract] Recent studies exploring the relationship between DNA damage measured by the comet assay (single-cell gel electrophoresis) and cognitive function in both animal models and humans are reviewed and summarized. ...
Association of torquetenovirus viremia with physical frailty and cognitive impairment in three independent european cohorts
(Karger, 2023-01-10)
[Abstract] Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, ...
Serum cortisol but not oxidative stress biomarkers are related to frailty: results of a cross-sectional study in Spanish older adults
(Taylor&Francis, 2019-08-13)
[Abstract] Frailty is a multidimensional geriatric syndrome of loss of reserves and increased vulnerability to negative health outcomes. Cortisol, the major hormone of the hypothalamic pituitary adrenal (HPA) axis, and ...
Exploring genetic outcomes as frailty biomakers
(Oxford, 2018-04-19)
[Abstract] Frailty has emerged as a reliable measure of the aging process. Because the early detection of frailty is crucial to prevent or even revert it, the use of biomarkers would allow an earlier and more objective ...
Immune activation in older-aged individuals is associated with genetic instability (or vice versa)
(De Gruyter, 2019-06-15)
Frailty in older adults Is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations
(Frontiers, 2018-05-16)
[Abstract] Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related ...
Frailty syndrome and genomic instability in older adults: suitability of the cytome micronucleus assay as a diagnostic tool
(Oxford, 2018-01-13)
[Abstract] Frailty, a condition involving increased risk of disability and mortality in older adults, has emerged as a reliable way to predict the effect of aging. Genomic instability may help to anticipate recognition of ...
Immune biomarkers in older adults: role of physical activity
(Taylor & Francis, 2017-05-19)
[Abstract] Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and ...
Frailty status in older adults is related to alterations in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways
(Elsevier para AMDA (The Society for Post-Acute and Long-Term Cara Medicine), 2017-08-08)
Effects of degree of urbanization and lifetime longest-held occupation on cognitive impairment prevalence in an older spanish population
(Frontiers, 2017-02-13)
[Abstract] Our aim was to estimate the prevalence of cognitive impairment in rural and urban elderly populations and to examine the relationship between lifetime occupation and general cognitive performance. A cross-sectional ...