Browsing GI- NANOSELF4BIO - Artigos by Issue Date
Now showing items 1-20 of 45
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Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment
(MDPI, 2018)[Abstract] The repair of focal articular cartilage defects remains a problem. Combining gene therapy with tissue engineering approaches using bone marrow-derived mesenchymal stem cells (MSCs) may allow the development of ... -
Aggregation of Vibrio cholerae by Cationic Polymers Enhances Quorum Sensing but Overrides Biofilm Dissipation in Response to Autoinduction
(American Chemical Society, 2018)[Abstract] Vibrio cholerae is a Gram-negative bacterium found in aquatic environments and a human pathogen of global significance. Its transition between host-associated and environmental lifestyles involves the tight ... -
Microwave-Induced Covalent Functionalization of Few-Layer Graphene with Arynes under Solvent-Free Conditions
(Royal Society of Chemistry, 2018-07-04)[Abstract]: A non-conventional modification of exfoliated few-layer graphene (FLG) with different arynes under microwave (MW) irradiation and solvent-free conditions is reported. The described approach allows reaching fast, ... -
Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery
(MDPI, 2019)[Abstract] Controlled delivery of gene transfer vectors is a powerful strategy to enhance the temporal and spatial presentation of therapeutic agents in a defined target. Hydrogels are adapted biomaterials for gene delivery ... -
Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment
(MDPI, 2019)[Abstract] Gene therapy for osteoarthritis offers powerful, long-lasting tools that are well adapted to treat such a slow, progressive disorder, especially those therapies based on the clinically adapted recombinant ... -
Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers
(Royal Society of Chemistry, 2019)[Abstract] Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between ... -
Poly(Boc-acryloyl hydrazide): the importance of temperature and RAFT agent degradation on its preparation
(Royal Society of Chemistry, 2019)[Abstract] Poly(acryloyl hydrazide) is a versatile polymer scaffold readily functionalised through post-polymerisation modification with aldehydes to yield polymers for biological applications. However, its polymerisation ... -
The Reactivity of Reduced Graphene Depends on Solvation
(IOP Publishing, 2019-02-01)[Abstract] The reactivity of reduced graphene sheets (graphenide), obtained by dissolution of graphite intercalation compounds, in particular KC8, was systemically studied by cova-lent functionalization with 4-fluorobenz ... -
High-Yield Preparation of Exfoliated 1T-MoS2 with SERS Activity
(American Chemical Society, 2019-07-17)[Abstract]: Molybdenum disulfide (MoS2), a promising two-dimensional transition-metal dichalcogenide, presents a challenge in the tuning of its optoelectronic and chemical properties. Herein, we demonstrate an efficient ... -
Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer
(MDPI, 2020)[Abstract] Background: The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while ... -
Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects
(WILEY-VCH, 2020)[Abstract] Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled and minimally invasive delivery ... -
Site-Selective and Rewritable Labeling of DNA through Enzymatic, Reversible, and Click Chemistries
(American Chemical Society, 2020)[Abstract] Current methods for bioconjugation rely on the introduction of stable linkers that lack the required versatility to perform sequential functionalizations. However, sequential manipulations are an increasing ... -
Mass Spectrometry of Carbohydrate-Protein Interactions on a Glycan Array Conjugated to CVD Graphene Surfaces
(IOP, 2020-01-06)[Abstract]: Mass spectrometry (MS) is a valuable tool for functional genomic, proteomic, and glycomic studies. In particular, the combination of MS with microarrays is a powerful technique for analyzing the activity of ... -
Concise, Single-Step Synthesis of Sulfur-Enriched Graphene: Immobilization of Molecular Clusters and Battery Applications
(Wiley-VCH, 2020-02-11)[Abstract]: The concise synthesis of sulfur-enriched Graphene for battery applications is reported. The direct treatment of graphene oxide (GO) with the commercially available Lawesson’s reagent produced sulfur-enriched-reduced ... -
Graphene, Other Carbon Nanomaterials and the Immune System: Toward Nanoimmunity-By-Design
(IOP Publishing, 2020-07-13)[Abstract]: Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted a great deal scientific attention due to their potential as biomedical tools. Following exposure, ... -
Water-Mediated ElectroHydrogenation of CO2 at Near-Equilibrium Potential by Carbon Nanotubes/Cerium Dioxide Nanohybrids
(American Chemical Society, 2020-08-19)[Abstract]: The combination of multiwalled carbon nanotubes (MWCNTs) with undoped CeO2 na-noparticles (NPs) is effective for the direct electrocatalytic reduction of CO2 to formic acid (FA) at acidic pH (0.1 M HNO3), at ... -
Light-driven, heterogeneous organocatalysts for C–C bond formation toward valuable perfluoroalkylated intermediates
(American Association for the Advancement of Science, 2020-11-11)The favorable exploitation of carbon nitride (CN) materials in photocatalysis for organic synthesis requires the appropriate fine-tuning of the CN structure. Here, we present a deep investigation of the structure/activity ... -
Electrochemically Controlled Cleavage of Imine Bonds on a Graphene Platform: Towards New Electro-Responsive Hybrids for Drug Release
(Royal Society of Chemistry, 2020-11-25)[Abstract] Graphene-based materials are particularly suitable platforms for the development of new systems able to release drugs upon the application of controlled electrochemical stimuli. Herein, we report a new ... -
Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo
(Wiley-VCH, 2021)[Abstract] The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial-guided gene therapy ... -
Metal Nanoparticles/MoS2 Surface-Enhanced Raman Scattering- Based Sandwich Immunoassay for α‑Fetoprotein Detection
(American Chemical Society, 2021-02-13)[Abstract]: The detection of cancer biomarkers at an early stage of tumor development is vital for effective diagnosis and treatment of cancer. Current diagnostic tools can often detect cancer only when the biomarker levels ...