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Reversible Control of DNA Binding with Cucurbit[8]uril-Induced Supramolecular 4,4′-Bipyridinium–Peptide Dimers
dc.contributor.author | Novo, Paula | |
dc.contributor.author | García, Marcos D. | |
dc.contributor.author | Peinador, Carlos | |
dc.contributor.author | Pazos, Elena | |
dc.date.accessioned | 2021-11-04T12:13:16Z | |
dc.date.available | 2021-11-04T12:13:16Z | |
dc.date.issued | 2021-03-08 | |
dc.identifier.citation | Novo, P., García, M. D., Peinador, C. and Pazos, E. (2021) Reversible control of DNA binding with cucurbit[8]uril-induced supramolecular 4,4′-Bipyridinium–Peptide dimers. Bioconjugate chemistry. 32, 3, 507-511. https://doi.org/10.1021/acs.bioconjchem.1c00063 | es_ES |
dc.identifier.issn | 1043-1802 | |
dc.identifier.issn | 1520-4812 | |
dc.identifier.uri | http://hdl.handle.net/2183/28799 | |
dc.description | Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG | |
dc.description | The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00063 | |
dc.description.abstract | [Abstract] Many cellular processes in living organisms are regulated by complex regulatory networks, built from noncovalent interactions between relatively few proteins that perform their functions by switching between homo- and heterooligomeric assemblies or mono- and bivalent states. Herein, we demonstrate that the conjugation of a 4,4′-bipyridinium scaffold to the basic region of the GCN₄ bZip transcription factor can be exploited to control the dimerization of the conjugate by formation of a supramolecular complex with cucurbit[8]uril. Importantly, this supramolecular complex is able to specifically recognize its target dsDNA, and this binding can be reversibly switched by the application of external stimuli. | es_ES |
dc.description.sponsorship | We are thankful for the funding received from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 851179), the Ministerio de Economía y Competitividad and Fondo Europeo de Desarrollo Regional (FEDER) (CTQ2016-75629-P), the Agencia Estatal de Investigación and FEDER (CTQ2017-89166-R and PID2019-105272GB-I00) and the Consellería de Educación, Universidade e Formación Profesional, Xunta de Galicia (ED431C 2018/39). P.N thanks the Ministerio de Ciencia, Innovación y Universidades for her PhD fellowship (FPU17/04357). E.P. thanks the UDC-Inditex InTalent Programme for her research contract and funding and the Xunta de Galicia for the Oportunius Programme | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C 2018/39 | es_ES |
dc.description.uri | https://pubs.acs.org/doi/suppl/10.1021/acs.bioconjchem.1c00063/suppl_file/bc1c00063_si_001.pdf | |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/851179 | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-75629-P/ES/NUEVOS SISTEMAS SUPRAMOLECULARES DINAMICOS. ESTABILIZACION SELECTIVA DE G-QUADRUPLEXES CON ESTRUCTURAS METALOCICLICAS | |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-89166-R/ES/HERRAMIENTAS PEPTIDICAS PARA APLICACIONES BIOLOGICAS: SENSORES INTELIGENTES PARA ESTUDIAR NITRACION DE PROTEINAS Y NANOMATERIALES CON FUNCIONALIDADES MODULABLES | |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105272GB-I00/ES/DESARROLLO DE NUEVOS CICLOFANOS AUTOENSAMBLADOS Y SU IMPLEMENTACION EN ESTRUCTURAS NANOMETRICAS | |
dc.relation | info:eu-repo/grantAgreement/MECD/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FPU17%2F04357/ES/ | |
dc.relation.uri | https://doi.org/10.1021/acs.bioconjchem.1c00063 | es_ES |
dc.rights | Atribución 4.0 Internacional | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Reversible Control of DNA Binding with Cucurbit[8]uril-Induced Supramolecular 4,4′-Bipyridinium–Peptide Dimers | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Bioconjugate Chemistry | es_ES |
UDC.volume | 32 | es_ES |
UDC.issue | 3 | es_ES |
UDC.startPage | 507 | es_ES |
UDC.endPage | 511 | es_ES |
dc.identifier.doi | 10.1021/acs.bioconjchem.1c00063 |
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