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Platelet-rich plasma in osteoarthritis treatment: review of current evidence
dc.contributor.author | Gato Calvo, Lucía | |
dc.contributor.author | Magalhaes, J. | |
dc.contributor.author | Ruiz-Romero, Cristina | |
dc.contributor.author | Blanco García, Francisco J | |
dc.contributor.author | Burguera, Elena F. | |
dc.date.accessioned | 2020-03-13T11:25:15Z | |
dc.date.available | 2020-03-13T11:25:15Z | |
dc.date.issued | 2019-02-19 | |
dc.identifier.citation | Gato-Calvo L, Magalhaes J, Ruiz-Romero C, Blanco FJ, Burguera EF. Platelet-rich plasma in osteoarthritis treatment: review of current evidence. Ther Adv Chronic Dis. 2019 Feb 19;10:2040622319825567. | es_ES |
dc.identifier.issn | 2040-6223 | |
dc.identifier.uri | http://hdl.handle.net/2183/25172 | |
dc.description | Review | es_ES |
dc.description.abstract | [Abstract] Platelet-rich plasma (PRP) is defined as a volume of plasma with a platelet concentration higher than the average in peripheral blood. Many basic, preclinical and even clinical case studies and trials report PRP’s ability to improve musculoskeletal conditions including osteoarthritis, but paradoxically, just as many conclude it has no effect. The purpose of this narrative review is to discuss the available relevant evidence that supports the clinical use of PRP in osteoarthritis, highlighting those variables we perceive as critical. Here, recent systematic reviews and meta-analyses were used to identify the latest randomized controlled trials (RCTs) testing a PRP product as an intra-articular treatment for knee osteoarthritis, compared with an intra-articular control (mostly hyaluronic acid). Conclusions in the identified RCTs are examined and compared. In total, five recent meta-analyses and systematic reviews were found meeting the above criteria. A total of 19 individual trials were identified in the five reviews but only 9 were level of evidence I RCTs, and many had moderate or high risks of bias. At present, results from these RCTs seem to favor PRP use over other intra-articular treatments to improve pain scales in the short and medium term (6–12 months), but the overall level of evidence is low. As a result, clinical effectiveness of PRP for knee osteoarthritis treatment is still under debate. This is, prominently, the result of a lack of standardization of PRP products, scarceness of high quality RCTs not showing high risks of bias, and poor patient stratification for inclusion in the RCTs. | es_ES |
dc.description.sponsorship | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: LGC is supported by contract FPU13/06041 (Ministerio de Educación, Cultura y Deporte). CRR is supported by the Miguel Servet program contract CPII15/00013 and EFB is supported by Grant PMP15/00032 both from Fondo Investigación Sanitaria-Spain. This work was supported by grants PI12/00329 and PI16/02124 (Fondo de Investigación Sanitaria), IN607A 2017/11 from Axencia Galega de Innovación (GAin) and project 0245_IBEROS_1_E, an Interreg (POCTEP)-EU Program with FEDER funds. CIBER-BBN is a national initiative of the Instituto de Salud Carlos III. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MECD/Programa Estatal de Promoción del Talento y su Empleabilidad/FPU13%2F06041/ES/ | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/CPII15%2F00013/ES/ | |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PMP15%2F00032/ES/CLINICAL VALIDATION OF GENETIC MARKERS TO PREDICT PERSISTENT REMISSION IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH BIOLOGICAL THERAPY (REMRABIT) | |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Acción Estratégica de Salud/PI12%2F00329/ES/PROYECTO PROTEOMA HUMANO ESPAÑOL: Aplicacion en Enfermedades Reumatologicas | |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16%2F02124/ES/Determinación de índices predictivos de diagnóstico y pronóstico de artrosis de rodilla mediante la validación de biomarcadores proteicos | |
dc.description.sponsorship | Xunta de Galicia; IN607A 2017/11 | |
dc.language.iso | eng | es_ES |
dc.publisher | Sage | es_ES |
dc.relation.uri | https://doi.org/10.1177%2F2040622319825567 | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial 4.0 International License (CC-BY-NC 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Allogenic products | es_ES |
dc.subject | Anti-inflammatory intra-articular therapies | es_ES |
dc.subject | Clinical evidence | es_ES |
dc.subject | Clinical trials | es_ES |
dc.subject | Knee osteoarthritis | es_ES |
dc.subject | Patient stratification | es_ES |
dc.subject | Platelet rich plasma | es_ES |
dc.title | Platelet-rich plasma in osteoarthritis treatment: review of current evidence | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Therapeutic Advances in Chronic Diseases | es_ES |
UDC.volume | 10 | es_ES |
UDC.startPage | 2040622319825567 | es_ES |
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