Mostrar o rexistro simple do ítem
A data mining approach for classification of orthostatic and essential tremor based on MRI‐derived brain volume and cortical thickness
dc.contributor.author | Benito-León, Julián | |
dc.contributor.author | Louis, Elan D. | |
dc.contributor.author | Mato-Abad, Virginia | |
dc.contributor.author | Sánchez‐Ferro, Alvaro | |
dc.contributor.author | Romero, Juan Pablo | |
dc.contributor.author | Matarazzo, Michele | |
dc.contributor.author | Serrano, J. Ignacio | |
dc.date.accessioned | 2019-12-10T16:15:05Z | |
dc.date.available | 2019-12-10T16:15:05Z | |
dc.date.issued | 2019-11-26 | |
dc.identifier.citation | Benito‐León, J., Louis, E. D., Mato‐Abad, V., Sánchez‐Ferro, A., Romero, J. P., Matarazzo, M., & Serrano, J. I. (2019). A data mining approach for classification of orthostatic and essential tremor based on MRI‐derived brain volume and cortical thickness. Annals of clinical and translational neurology. | es_ES |
dc.identifier.issn | 2328-9503 | |
dc.identifier.uri | http://hdl.handle.net/2183/24459 | |
dc.description.abstract | [Abstract] Objective - Orthostatic tremor (OT) is an extremely rare, misdiagnosed, and underdiagnosed disorder affecting adults in midlife. There is debate as to whether it is a different condition or a variant of essential tremor (ET), or even, if both conditions coexist. Our objective was to use data mining classification methods, using magnetic resonance imaging (MRI)‐derived brain volume and cortical thickness data, to identify morphometric measures that help to discriminate OT patients from those with ET. Methods - MRI‐derived brain volume and cortical thickness were obtained from 14 OT patients and 15 age‐, sex‐, and education‐matched ET patients. Feature selection and machine learning methods were subsequently applied. Results - Four MRI features alone distinguished the two, OT from ET, with 100% diagnostic accuracy. More specifically, left thalamus proper volume (normalized by the total intracranial volume), right superior parietal volume, right superior parietal thickness, and right inferior parietal roughness (i.e., the standard deviation of cortical thickness) were shown to play a key role in OT and ET characterization. Finally, the left caudal anterior cingulate thickness and the left caudal middle frontal roughness allowed us to separate with 100% diagnostic accuracy subgroups of OT patients (primary and those with mild parkinsonian signs). Conclusions - A data mining approach applied to MRI‐derived brain volume and cortical thickness data may differentiate between these two types of tremor with an accuracy of 100%. Our results suggest that OT and ET are distinct conditions. | es_ES |
dc.description.sponsorship | National Institutes of Health (United States); #R01, NS39422 | es_ES |
dc.description.sponsorship | National Institutes of Health (United States), #R01, NS094607 | es_ES |
dc.description.sponsorship | National Institutes of Health (United States); #R01, NS085136 | es_ES |
dc.description.sponsorship | National Institutes of Health (United States); #R01, NS073872 | es_ES |
dc.description.sponsorship | National Institutes of Health (United States); #R01, NS085136 | es_ES |
dc.description.sponsorship | National Institutes of Health (United States); #R01, NS088257 | es_ES |
dc.description.sponsorship | European Commission; ICT‐2011‐287739 | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad; RTC‐2015‐3967‐1 | es_ES |
dc.description.sponsorship | Agencia Española de Investigación de la Salud; FIS PI12/01602 | es_ES |
dc.description.sponsorship | Agencia Española de Investigación de la Salud; FIS PI16/00451 | es_ES |
dc.description.sponsorship | Madrid Robotics Digital Innovation Hub; S2018/NMT‐4331 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons Ltd. | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/ 291820 | es_ES |
dc.relation.uri | https://doi.org/10.1002/acn3.50947 | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Data mining | es_ES |
dc.subject | Orthostatic and essential tremor | es_ES |
dc.subject | Magnetic resonance imaging | es_ES |
dc.subject | Essential tremor | es_ES |
dc.title | A data mining approach for classification of orthostatic and essential tremor based on MRI‐derived brain volume and cortical thickness | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Annals of Clinical and Translational Neurology | es_ES |
dc.identifier.doi | 10.1002/acn3.50947 |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
GI-ISLA-Artigos [19]
-
OpenAIRE [357]