AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients
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AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patientsAutor(es)
Fecha
2019-07-23Cita bibliográfica
Núñez L, Marrón-Liñares GM, Crespo-Leiro MG et al. AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients. PloS One. 2019; 14(7):e0219345.
Resumen
[Abstract] Introduction.
One of the main problems involved in heart transplantation (HT) is antibody-mediated rejection
(AMR). Many aspects of AMR are still unresolved, including its etiology, diagnosis and
treatment. In this project, we hypothesize that variants in genes involved in B-cell biology in
HT patients can yield diagnostic and prognostic information about AMR.
Methods.
Genetic variants in 61 genes related to B-cell biology were analyzed by next generation
sequencing in 46 HT patients, 23 with and 23 without AMR.
Results.
We identified 3 single nucleotide polymorphisms in ITGA4 gene (c.1845G>A, c.2633A>G,
and c.2883C>T) that conformed the haplotype AGT-ITGA4. This haplotype is associated
with the development of AMR. Moreover, AMR patients with the haplotype AGT-ITGA4
present lower levels of integrin α-4 in serum samples compared to the reference GAC haplotype
in control patients.
Conclusion.
We can conclude that polymorphisms in genes related to the biology of B-cells could have
an important role in the development of AMR. In fact, the AGT haplotype in ITGA4 gene
could potentially increase the risk of AMR.
Versión del editor
Derechos
Atribución 4.0 Internacional
ISSN
1932-6203