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Involvement of HisF in the persistence of Acinetobacter baumannii during a pneumonia infection
dc.contributor.author | Martínez-Guitián, Marta | |
dc.contributor.author | Vázquez-Ucha, Juan Carlos | |
dc.contributor.author | Álvarez-Fraga, Laura | |
dc.contributor.author | Conde-Pérez, Kelly | |
dc.contributor.author | Lasarte-Monterrubio, Cristina | |
dc.contributor.author | Vallejo, J. A. | |
dc.contributor.author | Bou, Germán | |
dc.contributor.author | Poza, Margarita | |
dc.contributor.author | Beceiro, Alejandro | |
dc.date.accessioned | 2019-10-10T13:00:01Z | |
dc.date.available | 2019-10-10T13:00:01Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Martínez-Guitián M, Vázquez-Ucha JC, Álvarez-Fraga L, Conde-Pérez K, Lasarte-Monterrubio C, Vallejo JA, Bou G, Poza M and Beceiro A (2019) Involvement of HisF in the Persistence of Acinetobacter baumannii During a Pneumonia Infection. Front. Cell. Infect. Microbiol. 9:310. doi: 10.3389/fcimb.2019.00310 | es_ES |
dc.identifier.issn | 2235-2988 | |
dc.identifier.uri | http://hdl.handle.net/2183/24087 | |
dc.description.abstract | [Abstract] Acinetobacter baumannii is currently considered one of themost problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii was found over-expressed during the course of murine pneumonia infections. The study demonstrated that the A. baumannii ATCC 17978 mutant strain lacking the hisF gene induces a sub-lethal pneumonia infection in mice, while the complemented mutant strain increased its virulence. This histidine auxotroph mutant showed an increase on IL-6 secretion and leukocytes recruitment during infections. Furthermore, data revealed that the hisF gene, implicated in the innate immunity and inflammation, is involved in virulence during a pneumonia infection, which may partly explain the ability of this strain to persist in the lung. We suggest that HisF, essential for full virulence in this pathogen, should be considered a potential target for developing new antimicrobial therapies against A. baumannii. | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; PI15/00860 | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; PI14/00059 | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; PI17/01482 | es_ES |
dc.description.sponsorship | Axencia Galega de Innovación; IN607A 2016/22 | es_ES |
dc.description.sponsorship | Spanish Network for Research in Infectious Diseases; REIPI RD12/0015/0014 | es_ES |
dc.description.sponsorship | Spanish Network for Research in Infectious Diseases; REIPI RD16/0016/006 | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; FI18/00315 | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN606A-2019/029 | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN607A 2016/22 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers | es_ES |
dc.relation.uri | https://doi.org/10.3389/fcimb.2019.00310 | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | HisF | es_ES |
dc.subject | Mice pneumonia model | es_ES |
dc.subject | Lung infection | es_ES |
dc.subject | Acinetobacter baumannii | es_ES |
dc.subject | Virulence | es_ES |
dc.title | Involvement of HisF in the persistence of Acinetobacter baumannii during a pneumonia infection | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Frontiers in Cellular and Infection Microbiology | es_ES |
UDC.volume | 9 | es_ES |
UDC.startPage | 310 | es_ES |
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