Involvement of HisF in the persistence of Acinetobacter baumannii during a pneumonia infection
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Involvement of HisF in the persistence of Acinetobacter baumannii during a pneumonia infectionAutor(es)
Fecha
2019Cita bibliográfica
Martínez-Guitián M, Vázquez-Ucha JC, Álvarez-Fraga L, Conde-Pérez K, Lasarte-Monterrubio C, Vallejo JA, Bou G, Poza M and Beceiro A (2019) Involvement of HisF in the Persistence of Acinetobacter baumannii During a Pneumonia Infection. Front. Cell. Infect. Microbiol. 9:310. doi: 10.3389/fcimb.2019.00310
Resumen
[Abstract] Acinetobacter baumannii is currently considered one of themost problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii was found over-expressed during the course of murine pneumonia infections. The study demonstrated that the A. baumannii ATCC 17978 mutant strain lacking the hisF gene induces a sub-lethal pneumonia infection in mice, while the complemented mutant strain increased its virulence. This histidine auxotroph mutant showed an increase on IL-6 secretion and leukocytes recruitment during infections. Furthermore, data revealed that the hisF gene, implicated in the innate immunity and inflammation, is involved in virulence during a pneumonia infection, which may partly explain the ability of this strain to persist in the lung. We suggest that HisF, essential for full virulence in this pathogen, should be considered a potential target for developing new antimicrobial therapies against A. baumannii.
Palabras clave
HisF
Mice pneumonia model
Lung infection
Acinetobacter baumannii
Virulence
Mice pneumonia model
Lung infection
Acinetobacter baumannii
Virulence
Versión del editor
Derechos
Atribución 3.0 España
ISSN
2235-2988