Involvement of HisF in the persistence of Acinetobacter baumannii during a pneumonia infection
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Involvement of HisF in the persistence of Acinetobacter baumannii during a pneumonia infectionAuthor(s)
Date
2019Citation
Martínez-Guitián M, Vázquez-Ucha JC, Álvarez-Fraga L, Conde-Pérez K, Lasarte-Monterrubio C, Vallejo JA, Bou G, Poza M and Beceiro A (2019) Involvement of HisF in the Persistence of Acinetobacter baumannii During a Pneumonia Infection. Front. Cell. Infect. Microbiol. 9:310. doi: 10.3389/fcimb.2019.00310
Abstract
[Abstract] Acinetobacter baumannii is currently considered one of themost problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii was found over-expressed during the course of murine pneumonia infections. The study demonstrated that the A. baumannii ATCC 17978 mutant strain lacking the hisF gene induces a sub-lethal pneumonia infection in mice, while the complemented mutant strain increased its virulence. This histidine auxotroph mutant showed an increase on IL-6 secretion and leukocytes recruitment during infections. Furthermore, data revealed that the hisF gene, implicated in the innate immunity and inflammation, is involved in virulence during a pneumonia infection, which may partly explain the ability of this strain to persist in the lung. We suggest that HisF, essential for full virulence in this pathogen, should be considered a potential target for developing new antimicrobial therapies against A. baumannii.
Keywords
HisF
Mice pneumonia model
Lung infection
Acinetobacter baumannii
Virulence
Mice pneumonia model
Lung infection
Acinetobacter baumannii
Virulence
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Rights
Atribución 3.0 España
ISSN
2235-2988