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dc.contributor.authorDomarco, Olaya
dc.contributor.authorKieler, Claudia
dc.contributor.authorPirker, Christine
dc.contributor.authorDinhof, Carina
dc.contributor.authorEnglinger, Bernhard
dc.contributor.authorReisecker, Johannes M.
dc.contributor.authorTimelthaler, Gerald
dc.contributor.authorGarcía, Marcos D.
dc.contributor.authorPeinador, Carlos
dc.contributor.authorKeppler, Bernhard K.
dc.contributor.authorBerger, Walter
dc.contributor.authorTerenzi, Alessio
dc.date.accessioned2019-08-12T11:45:32Z
dc.date.available2019-08-12T11:45:32Z
dc.date.issued2019-04-19
dc.identifier.citationO. Domarco, C. Kieler, C. Pirker, C. Dinhof, B. Englinger, J. M. Reisecker, G. Timelthaler, M. D. García, C. Peinador, B. K. Keppler, W. Berger, A. Terenzi, Angew. Chem. Int. Ed. 2019, 58, 8007.es_ES
dc.identifier.issn1433-7851
dc.identifier.issn1521-3773
dc.identifier.urihttp://hdl.handle.net/2183/23720
dc.description.abstract[Abstract] Metal‐driven self‐assembly afforded a multitude of fascinating supramolecular coordination complexes (SCCs) with applications as catalysts, host–guest, and stimuli‐responsive systems. However, the interest in the biological applications of SCCs is only starting to emerge and thorough characterization of their behavior in biological milieus is still lacking. Herein, we report on the synthesis and detailed in‐cell tracking of a Pt2L2 metallacycle. We show that our hexagonal supramolecule accumulates in cancer cell nuclei, exerting a distinctive blue fluorescence staining of chromatin resistant to UV photobleaching selectively in nucleolar G4‐rich regions. SCC co‐localizes with epitopes of the quadruplex‐specific antibody BG4 and replaces other well‐known G4 stabilizers. Moreover, the photophysical changes accompanying the metallacycle binding to G4s in solution (fluorescence quenching, absorption enhancement) also take place intracellularly, allowing its subcellular interaction tracking.es_ES
dc.description.sponsorshipMinisterio de Economía, Industria y Competitividad; CTQ2016-75629-Pes_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/609431es_ES
dc.relation.urihttps://doi.org/10.1002/anie.201900934es_ES
dc.rightsAtribución-NoComercial 4.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/es/*
dc.subjectG-quadruplexes_ES
dc.subjectMetallacyclees_ES
dc.subjectPlatinumes_ES
dc.subjectSCCes_ES
dc.subjectSubcellular localizationes_ES
dc.titleSubcellular duplex DNA and G‐quadruplex interaction profiling of a hexagonal PtII metallacyclees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleAngewandte Chemie International Editiones_ES
UDC.volume58es_ES
UDC.issue54es_ES
UDC.startPage8007es_ES
UDC.endPage8012es_ES


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