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Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12
(Wiley, 2019-03-22)
[Abstract] Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expression in homeostasis, together with their ...
Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis
(BioMed Central, 2011-11-22)
[Abstract] Background: Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated ...
Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta-analysis and functional study
(BMJ, 2016-12-05)
[Abstract] Objective To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential ...
Mitochondrial haplogroups define two phenotypes of osteoarthritis
(Frontiers, 2012-05-11)
[Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA).
Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ...
Higher synovial immunohistochemistry reactivity of IL-17A, Dkk1, and TGF-β1 in patients with early psoriatic arthritis and rheumatoid arthritis could predict the use of biologics
(MDPI, 2024-04-08)
[Abstract] Background: Delay in diagnosis and therapy in patients with arthritis commonly leads to progressive articular damage. The study aimed to investigate the immunohistochemical reactivity of synovial cytokines ...
Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis
(BioMed Central, 2023-03-30)
[Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ...
Is osteoarthritis a mitochondrial disease?: what is the evidence
(Wolters Kluwer, 2022-01)
[Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease.
Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage ...
mtDNA haplogroup A enhances the effect of obesity on the risk of knee OA in a mexican population
(Nature, 2022-03-25)
[Abstract] To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. Samples were obtained from (n = 353) knee OA patients ...
Generating Rho-0 cells using mesenchymal stem cell lines
(PLoS, 2016-10-20)
[Abstract] Introduction, The generation of Rho-0 cells requires the use of an immortalization process, or tumor cell selection, followed by culture in the presence of ethidium bromide (EtBr), incurring the drawbacks its ...
In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis
(Elsevier, 2018-08-25)
[Abstract] Selective cyclooxigenase (COX)-2 inhibitors were developed to prevent traditional non-steroidal anti-inflammatory drugs (tNSAIDs) gastro-intestinal adverse effects. VA692, a recently disclosed selective COX-2 ...