• A single nucleotide polymorphism in the Il17ra promoter is associated with functional severity of ankylosing spondylitis 

      Vidal-Castiñeira, José Ramón; López-Vázquez, Antonio; Díaz-Peña, Alberto; Díaz-Bulnes, Paula; Martínez-Camblor, Pablo; Coto, Eliecer; Coto-Segura, Pablo; Bruges-Armas, Jacome; PInto, José Antonio; Blanco García, Francisco J; Sánchez, Alejandra; Mulero, Juan; Queiro, Rubén; López-Larrea, Carlos (PLoS, 2016-07-14)
      [Abstract] The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the ...
    • Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis 

      López-Lasanta, María; Juliá, Antonio; Maymó, Joan; Fernández-Gutiérrez, Benjamín; Ureña-Garnica, Inmaculada; Blanco García, Francisco J; Cañete, Juan D.; Alperi-López, Mercedes; Olivé, Alex; Corominas, Héctor; Tornero, Jesús; Erra, Alba; Almirall, Miriam; Palau, Nuria; Ortiz, Ana; Ávila, Gabriela; Rodríguez-Rodríguez, Luis; Alonso, Arnald; Tortosa, Raül; González-Álvaro, Isidoro; Marsal, Sara (BMC, 2015-09-04)
      [Abstract] Introduction. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. ...