ListarReumatoloxía por tema "DNA methylation"

Mostrando ítems 1-4 de 4

    • Epigenetics as a therapeutic target in osteoarthritis 

      Núñez-Carro, Carmen; Blanco-Blanco, Margarita; Villagrán-Andrade, Karla Mariuxi; Blanco García, Francisco J; Andrés, María C. de (MDPI, 2023-01-21)
      [Abstract] Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered ...

    • Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis 

      Juliá, Antonio; Gómez, Antonio; López-Lasanta, María; Blanco García, Francisco J; Erra, Alba; Fernández-Nebro, Antonio; Juan Mas, Antonio; Pérez-García, Carolina; García Vivar, María Luz; Sánchez-Fernández, Simón; Alperi-López, Mercedes; Sanmartí, Raimon; Ortiz, Ana María; Marras Fernández-Cid, Carlos; Díaz-Torné, César; Moreno, Estefanía; Li, Tianlu; Martínez-Mateu, Sergio H.; Absher, Devin M.; Myers, Richard M.; Tornero Molina, Jesús; Marsal, Sara (Elsevier, 2022-05-13)
      [Abstract] Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify ...

    • Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes 

      Cortés-Pereira, Estefanía; Fernández-Tajes, Juan; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Relaño, Sara; Ramos-Louro, Paula; Durán-Sotuela, Alejandro; Dalmao-Fernández, Andrea; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2019-02-12)
      [Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage. Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ...

    • Specific premature epigenetic aging of cartilage in osteoarthritis 

      Vidal-Bravo, Laura; López-Golán, Yolanda; Mera-Varela, Antonio; Rego-Pérez, Ignacio; Horvath, Steve; Zhang, Yuhua; Real, Álvaro del; Zhai, Guangju; Blanco García, Francisco J; Riancho, José A.; Gómez-Reino, Juan J.; González, Antonio (Impact Journals, 2016-09-28)
      [Abstract] Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, ...