Browsing Reumatoloxía by Author "Gomariz, Rosa P."
Now showing items 1-3 of 3
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Profile of matrix-remodeling proteinases in osteoarthritis: impact of fibronectin
Pérez-García, Selene; Carrión, Mar; Gutiérrez-Cañas, Irene; Villanueva-Romero, Raúl; Castro, David; Martínez, Carmen; González-Álvaro, Isidoro; Blanco García, Francisco J; Juarranz, Yasmina; Gomariz, Rosa P. (MDPI, 2019-12-22)[Abstract] The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes ... -
Proteomic analysis of synovial fibroblasts and articular chondrocytes co-cultures reveals valuable VIP-modulated inflammatory and degradative proteins in osteoarthritis
Pérez-García, Selene; Calamia, Valentina; Hermida Gómez, Tamara; Gutiérrez-Cañas, Irene; Carrión, Mar; Villanueva-Romero, Raúl; Castro, David; Martínez, Carmen; Juarranz, Yasmina; Blanco García, Francisco J; Gomariz, Rosa P. (MDPI, 2021-06-16)[Abstract] Osteoarthritis (OA) is the most common musculoskeletal disorder causing a great disability and a reduction in the quality of life. In OA, articular chondrocytes (AC) and synovial fibroblasts (SF) release ... -
Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12
Pérez-García, Selene; Carrión, Mar; Villanueva-Romero, Raúl; Hermida Gómez, Tamara; Fernández-Moreno, Mercedes; Mellado, Mario; Blanco García, Francisco J; Juarranz, Yasmina; Gomariz, Rosa P. (Wiley, 2019-03-22)[Abstract] Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expression in homeostasis, together with their ...