Listar Reumatoloxía por autor "Berenbaum, Francis"

Mostrando ítems 1-18 de 18

    • Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort 

      van Helvoort, Eefje M.; Ladel, Christoph H.; Mastbergen, Simon; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Widera, Pawel; Welsing, Paco M.J.; Lafeber, Floris (BMJ, 2021-08-23)
      [Abstract] Objectives: To describe the relations between baseline clinical characteristics of the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) participants and their predicted ...

    • Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis?: data from the IMI-APPROACH cohort 

      Jansen, Mylène P.; Hodgins, Diana; Mastbergen, Simon C.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Eckstein, Felix; Roemer, Frank W.; Wirt, Wolfgang (Springer Nature, 2024-03-27)
      [Abstract] Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected ...

    • Cohort profile: the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers 

      van Helvoort, Eefje M.; van Spil, Willem E.; Jansen, Mylène P.; Welsing, Paco M.J.; Kloppenburg, Margreet; Loef, Marieke; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bacardit, Jaume; Ladel, Christoph H.; Loughlin, John; Bay-Jensen, Anne C.; Mobasheri, Ali; Larkin, Jonathan; Boere, Janneke; Weinans, Harrie H.; Lalande, Agnes; Marijnissen, Anne C.A.; Lafeber, Floris (BMJ, 2020-07-28)
      [Abstract] Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) consortium intends to prospectively describe in detail, preselected patients with knee osteoarthritis (OA), using ...

    • Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib 

      Hochberg, Marc C.; Martel-Pelletier, Johanne; Monfort, Jordi; Möller, Ingrid; Castillo, Juan Ramón; Arden, Nigel; Berenbaum, Francis; Blanco García, Francisco J; Conaghan, Philip G.; Domènech, Gema; Henrotin, Yves; Pap, Thomas; Richette, Pascal; Sawitze, Allen; Souich, Patrick du; Pelletier, Jean-Pierre (BMJ, 2015-01-14)
      [Abstract] Objectives. To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. Methods. Double-blind ...

    • Core outcome measurement instrument selection for physical function in hand osteoarthritis using the OMERACT Filter 2.1 process 

      Kroon, Féline P.B.; van der Heijde, Désirée; Maxwell, Lara J.; Beaton, Dorcas E.; Abishek, Abishek; Berenbaum, Francis; Blanco García, Francisco J; Conaghan, Philip G.; Dziedzic, Krysia; Hill, Catherine L.; Haugen, Ida K.; Ishimori, Mariko; Ritschl, Valentin; Stamm, Tanja A.; Wittoek, Ruth; Kopplenburg, Margreet (Elsevier, 2021-12)
      [Abstract] Objective: Physical function is one of the Outcome Measures in Rheumatology (OMERACT) core outcome domains for hand osteoarthritis studies. Our aim was to select appropriate instrument(s) to measure this domain, ...

    • Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study 

      Widera, Pawel; Welsing, Paco M.J.; Danso, Samuel O.; Peelen, Sjaak; Kloppenburg, Margreet; Loef, Marieke; Marijnissen, Anne C.; van Helvoort, Eefje M.; Blanco García, Francico J; Magalhaes, Joana; Berenbaum, Francis; Haugen, Ida K.; Bay-Jensen, Anne-C.; Mobasheri, Ali; Ladel, Christoph; Loughlin, John; Lafeber, Floris P.J.G.; Lalande, Agnes; Larkin, Jonathan; Weinans, Harrie; Bacardit, Jaume (Elsevier, 2023-12)
      [Abstract] Objectives. To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine ...

    • GaitSmart motion analysis compared to commonly used function outcome measures in the IMI-APPROACH knee osteoarthritis cohort 

      van Helvoort, Eefje M.; Hodgings, Diana; Mastbergen, Simon; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris P.J.G.; Welsing, Paco M.J. (PLoS ONE, 2022-03-23)
      [Abstract] Background: There are multiple measures for assessment of physical function in knee osteoarthritis (OA), but each has its strengths and limitations. The GaitSmart® system, which uses inertial measurement units ...

    • Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort 

      Jansen, Mylène P.; Wirth, Wolfgang; Bacardit, Jaume; van Helvoort, Eefje M.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francico J; Haugen, Ida K.; Berenbaum, Francis; Ladel, Christoph H.; Loef, Marieke; Lafeber, Floris P.J.G.; Welsing, Paco M.J.; Mastbergen, Simon C.; Roemer, Frank W. (AME, 2023-05)
      [Abstract] In the Innovative Medicine’s Initiative Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee osteoarthritis (OA) study, machine learning models were trained to predict the ...

    • Neuropathic Pain in the IMI-APPROACH Knee Osteoarthritis Cohort: Prevalence and Phenotyping 

      van Helvoort, Eefje M.; Welsing, Paco M.J.; Jansen, Mylène P.; Gielis, Willem Paul; Loef, Marieke; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Bay-Jensen, Anne-C; Ladel, Christoph H.; Lalande, Agnes; Larkin, Jonathan; Loughlin, John; Mobasheri, Ali; Weinans, Harrie; Lafeber, Floris; Eijkelkamp, Niels; Mastbergen, Simon (BMJ, 2021-12-15)
      [Abstract] Objectives: Osteoarthritis (OA) patients with a neuropathic pain (NP) component may represent a specific phenotype. This study compares joint damage, pain and functional disability between knee OA patients with ...

    • Osteoarthritis endotype discovery via clustering of biochemical marker data 

      Angelini, Federico; Widera, Pawel; Mobasheri, Ali; Blair, Joseph; Struglics, André; Uebelhoer, Melanie; Hentorin, Yves; Marijnissen, Anne CA; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Ladel, Christoph; Larkin, Jonathan; Bay-Jensen, Anne C.; Bacardit, Jaume (BMJ, 2022-04-08)
      [Abstract] Objectives: Osteoarthritis (OA) patient stratification is an important challenge to design tailored treatments and drive drug development. Biochemical markers reflecting joint tissue turnover were measured in ...

    • Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion 

      Heiss, Rafael; Laredo, Jean-Denis; Wirth, Wolfgang; Jansen, Mylène P.; Marijnissen, Anne C.A.; Lafeber, Floris P.J.G.; Lalande, Agnes; Weinans, Harrie H.; Blanco García, Francico J; Berenbaum, Francis; Kloppenburg, Margreet; Haugen, Ida K.; Engelke, Klaus; Roemer, Frank W. (Elsevier, 2023-03)
      [Abstract] Objective: Osteoarthritis (OA) is a highly prevalent chronic condition. The subchondral bone plays an important role in onset and progression of OA making it a potential treatment target for disease-modifying ...

    • Relationship Between Motion, Using the GaitSmartTM System, and Radiographic Knee Osteoarthritis: An Explorative Analysis in the IMI-APPROACH Cohort 

      van Helvoort, Eefje M.; Hodgins, Diana; Mastbergen, Simon C.; Marijnissen, Anne Karien; Guehring, Hans; Loef, Marieke; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris; Welsing, Paco M.J. (Oxford, 2020-12-25)
      [Abstract] Objectives: To assess underlying domains measured by GaitSmartTMparameters and whether these are additional to established OA markers including patient reported outcome measures (PROMs) and radiographic parameters, ...

    • Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort 

      Roemer, Frank W.; Jansen, Mylène; Marijnissen, Anne C.A.; Guermazi, Ali; Heiss, Rafael; Maschek, Susanne; Lalande, Agnes; Blanco García, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida K.; Ladel, Christoph H.; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Lafeber, Floris P.J.G.; Weinans, Harrie H.; Wirth, Wolfgang (BioMed Central, 2022-11-17)
      [Abstract] Background. The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index ...

    • Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period 

      Berenbaum, Francis; Blanco García, Francisco J; Guermazi, Ali; Miki, Kenji; Yamabe, Takaharu; Viktrup, Lars; Junor, Rod; Carey, William; Brown, Mark T.; West, Christine R.; Verburg, Kenneth M. (BMJ, 2020-03-31)
      [Abstract] Objective. Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up. Methods. This double-blind, ...

    • Subcutaneous Tanezumab for Osteoarthritis: Is the Early Improvement in Pain and Function Meaningful and Sustained? 

      Berenbaum, Francis; Langford, R.; Perrot, S.; Miki, Kenji; Blanco García, Francisco J; Yamabe, Takaharu; Isogawa, N.; Junor, Rod; Carey, William; Viktrup, Lars; West, Christine R.; Brown, Mark T.; Verburg, Kenneth M. (Wiley, 2021-03-16)
      [Abstract] Background: To evaluate if early improvements in pain and function with subcuta-neous tanezumab are meaningful and sustained over 24 weeks. Methods: Patients with moderate- to- severe osteoarthritis (hip or ...

    • Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort 

      Wirth, Wolfgang; Maschek, Susanne; Marijnissen, Anne C.A.; Lalande, Agnes; Blanco García, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida K.; Ladel, Christoph H.; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Roemer, Frank W.; Lafeber, Floris P.J.G.; Weinans, Harrie H.; Jansen, Mylène (Elsevier, 2022-11-03)
      [Abstract] Objective. To investigate the test–retest precision and to report the longitudinal change in cartilage thickness, the percentage of knees with progression and the predictive value of the machine-learning-estimated ...

    • The association of the lipid profile with knee and hand osteoarthritis severity: the IMI-APPROACH cohort 

      Loef, Marieke; van de Stadt, L.; Böhringer, S.; Bay-Jensen, Anne-C.; Mobasheri, Ali; Larkin, Jonathan; Lafeber, Floris P.J.G.; Blanco García, Francisco J; Haugen, Ida K.; Berenbaum, Francis; Giera, M.; Ioan-Facsinay, Andreea; Kloppenburg, Margreet (Elsevier, 2022-05-27)
      [Abstract] Objective: To investigate the association of the lipidomic profile with osteoarthritis (OA) severity, considering the outcomes radiographic knee and hand OA, pain and function. Design: We used baseline data ...

    • Translation of clinical problems in osteoarthritis into pathophysiological research goals 

      van der Kraan, Peter M.; Berenbaum, Francis; Blanco García, Francisco J; De Bari, Cosimo; Lafeber, Floris; Hauge, Ellen; Higginbottom, Adele; Ioan-Facsinay, Andreea; Loughlin, John; Meulenbelt, Ingrid; Moilanen, Eeva; Pitsilidou, Irene; Tsezou, Aspasia; van Meurs, Joyce; Vincent, Tonia; Wittoek, Ruth; Lories, Rik (BMJ, 2016-05-26)
      [Abstract] Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent ...