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dc.contributor.authorBlanco, Moisés
dc.contributor.authorTarrío, Nuria
dc.contributor.authorReboredo, Margarita
dc.contributor.authorHaz, Mar
dc.contributor.authorGarcía, Jorge
dc.contributor.authorQuindós-Varela, María
dc.contributor.authorFigueroa, Angélica
dc.contributor.authorAntón-Aparicio, Luis M.
dc.contributor.authorCalvo, Lourdes
dc.contributor.authorValladares-Ayerbes, Manuel
dc.date.accessioned2019-02-20T12:17:59Z
dc.date.available2019-02-20T12:17:59Z
dc.date.issued2014-06-20
dc.identifier.citationBlanco-Calvo M, Tarrío N, Reboredo M, et al. Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer. Future Oncol. 2014; 10(7): 1187-1202es_ES
dc.identifier.issn1479-6694
dc.identifier.urihttp://hdl.handle.net/2183/21886
dc.description.abstract[Abstract] Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. Patients & methods: Fifty-two GC and 23 control samples were included. Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033). Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; PI061541es_ES
dc.description.sponsorshipXunta de Galicia; PS0877es_ES
dc.language.isoenges_ES
dc.publisherFuture Sciencees_ES
dc.relation.urihttps://doi.org/10.2217/fon.13.263es_ES
dc.subjectBiomakerses_ES
dc.subjectDiagnostices_ES
dc.subjectGastric canceres_ES
dc.subjectGDF15es_ES
dc.subjectMetastasises_ES
dc.subjectmiR-200ces_ES
dc.subjectMMP7es_ES
dc.subjectPrognostices_ES
dc.titleCirculating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleFuture Oncologyes_ES
UDC.volume10es_ES
UDC.issue7es_ES
UDC.startPage1187es_ES
UDC.endPage1202es_ES


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