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Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer
dc.contributor.author | Blanco, Moisés | |
dc.contributor.author | Tarrío, Nuria | |
dc.contributor.author | Reboredo, Margarita | |
dc.contributor.author | Haz, Mar | |
dc.contributor.author | García, Jorge | |
dc.contributor.author | Quindós-Varela, María | |
dc.contributor.author | Figueroa, Angélica | |
dc.contributor.author | Antón-Aparicio, Luis M. | |
dc.contributor.author | Calvo, Lourdes | |
dc.contributor.author | Valladares-Ayerbes, Manuel | |
dc.date.accessioned | 2019-02-20T12:17:59Z | |
dc.date.available | 2019-02-20T12:17:59Z | |
dc.date.issued | 2014-06-20 | |
dc.identifier.citation | Blanco-Calvo M, Tarrío N, Reboredo M, et al. Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer. Future Oncol. 2014; 10(7): 1187-1202 | es_ES |
dc.identifier.issn | 1479-6694 | |
dc.identifier.uri | http://hdl.handle.net/2183/21886 | |
dc.description.abstract | [Abstract] Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed. Patients & methods: Fifty-two GC and 23 control samples were included. Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033). Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients. | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; PI061541 | es_ES |
dc.description.sponsorship | Xunta de Galicia; PS0877 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Future Science | es_ES |
dc.relation.uri | https://doi.org/10.2217/fon.13.263 | es_ES |
dc.subject | Biomarker | es_ES |
dc.subject | Diagnostic | es_ES |
dc.subject | Gastric cancer | es_ES |
dc.subject | GDF15 | es_ES |
dc.subject | Metastasis | es_ES |
dc.subject | miR-200c | es_ES |
dc.subject | MMP7 | es_ES |
dc.subject | Prognostic | es_ES |
dc.title | Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Future Oncology | es_ES |
UDC.volume | 10 | es_ES |
UDC.issue | 7 | es_ES |
UDC.startPage | 1187 | es_ES |
UDC.endPage | 1202 | es_ES |
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