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dc.contributor.authorMarcos-Pérez, Diego
dc.contributor.authorSánchez-Flores, María
dc.contributor.authorMaseda, Ana
dc.contributor.authorLorenzo-López, Laura
dc.contributor.authorMillán-Calenti, José Carlos
dc.contributor.authorGostner, Johanna M.
dc.contributor.authorFuchs, Dietmar
dc.contributor.authorPasaro, Eduardo
dc.contributor.authorLaffon, Blanca
dc.contributor.authorValdiglesias, Vanessa
dc.date.accessioned2019-01-22T11:26:27Z
dc.date.available2019-01-22T11:26:27Z
dc.date.issued2018-05-16
dc.identifier.citationMarcos-Pérez D, Sánchez-Flores M, Maseda A, et al. Frailty in older adults Is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulations. Front Immunol. 2018; 9: 1056es_ES
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/2183/21614
dc.description.abstract[Abstract] Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related alterations of the immune system may compromise its competence culminating in a chronic low-grade inflammation state. Thus, it has been proposed that frailty is associated with alterations in the concentration of pro-inflammatory molecules and in different lymphocyte subpopulations. To provide further support to the validity of that hypothesis, we conducted a cross-sectional study in a population of Spanish older adults (N = 259, aged 65 and over) classified according to their frailty status. Biomarkers analyzed included percentages of several lymphocyte subsets and several inflammation mediators, namely concentrations of interleukin 6 (IL6), C-reactive protein (CRP), tumor necrosis factor α (TNFα), and 75 kDa soluble TNFα receptor II (sTNF-RII). Reference ranges for the inflammation mediators were established for the first time in robust older adults. A significant increase in the CD4+/CD8+ ratio and a significant decrease in the % CD19+ cells were observed in the frail group. Progressive increases with frailty severity were obtained in all inflammatory mediator concentrations, especially notable for IL6 and sTNF-RII. Area under the receiver-operating characteristic curve obtained for sTNF-RII (0.90, 95% CI 0.85–0.94, P < 0.001) indicates a high accuracy in the predictive value of this biomarker for frailty. Although results from the current study revealed limited strength associations between frailty and the lymphocyte subsets assessed, data obtained for the inflammatory mediators provide further support to involvement of inflammaging in frailty status in older adults.es_ES
dc.description.sponsorshipXunta de Galicia; ED431B 2016/013es_ES
dc.description.sponsorshipXunta de Galicia; ED431C 2017/49es_ES
dc.description.sponsorshipXunta de Galicia; IN607C 2016/08es_ES
dc.language.isoenges_ES
dc.publisherFrontierses_ES
dc.relation.urihttps://doi.org/10.3389/fimmu.2018.01056es_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectC-reactive proteines_ES
dc.subjectInterleukin 6es_ES
dc.subjectFrailtyes_ES
dc.subjectInflammaginges_ES
dc.subjectLymphocyte subpopulationses_ES
dc.subjectTumor necrosis factor alphaes_ES
dc.subjectSoluble TNF alpha receptor IIes_ES
dc.titleFrailty in older adults Is associated with plasma concentrations of inflammatory mediators but not with lymphocyte subpopulationses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleFrontiers in Immunologyes_ES
UDC.volume9es_ES


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