The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the difference
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The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the differenceAutor(es)
Data
2017-09-07Cita bibliográfica
The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the difference. M. Le Fur, M. Beyler, E. Molnár, O. Fougère, D. Esteban-Gómez, G. Tircsó, C. Platas-Iglesias, N. Lepareur, O. Rousseaux and R. Tripier, Chem. Commun., 2017, 53, 9534–9537.
Resumo
[Abstract] Thanks to a smart regiospecific N-functionalization, a pyclen based ligand bearing one picolinate and two acetate arms organized in a dissymmetric manner was synthesized for Y3+ complexation, and compared to its symmetric analogue. The nature of the capping bonds around the metal coordination environment has a dramatic effect on the properties of the chelate, the natY3+ and 90Y3+ dissymmetric derivatives presenting enhanced thermodynamic stability and kinetic inertness.
Palabras chave
Thermodynamic stability
DFT calculations
Yttrium complexes
Pyclen ligands
Radiotherapy
DFT calculations
Yttrium complexes
Pyclen ligands
Radiotherapy
Versión do editor
ISSN
1359-7345
1364-548X
1364-548X