The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the difference
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The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the differenceAuthor(s)
Date
2017-09-07Citation
The role of the capping bond effect on pyclen natY3+/90Y3+ chelates: full control of the regiospecific N-functionalization makes the difference. M. Le Fur, M. Beyler, E. Molnár, O. Fougère, D. Esteban-Gómez, G. Tircsó, C. Platas-Iglesias, N. Lepareur, O. Rousseaux and R. Tripier, Chem. Commun., 2017, 53, 9534–9537.
Abstract
[Abstract] Thanks to a smart regiospecific N-functionalization, a pyclen based ligand bearing one picolinate and two acetate arms organized in a dissymmetric manner was synthesized for Y3+ complexation, and compared to its symmetric analogue. The nature of the capping bonds around the metal coordination environment has a dramatic effect on the properties of the chelate, the natY3+ and 90Y3+ dissymmetric derivatives presenting enhanced thermodynamic stability and kinetic inertness.
Keywords
Thermodynamic stability
DFT calculations
Yttrium complexes
Pyclen ligands
Radiotherapy
DFT calculations
Yttrium complexes
Pyclen ligands
Radiotherapy
Editor version
ISSN
1359-7345
1364-548X
1364-548X