Now showing items 1-4 of 4
New insights into molecular mechanisms of sunitinib-associated side effects
(American Association for Cancer Research, 2011-12)
[Abstract] The introduction of targeted therapy represents a major advance in the treatment of tumor progression. Targeted agents are a novel therapeutic approach developed to disrupt different cellular signaling pathways. ...
Hakai reduces cell-substratum adhesion and increases epithelial cell invasion
(BioMed Central, 2011-11-03)
[Abstract] Background. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the ...
Sunitinib-induced asthenia: from molecular basis to clinical relief
(Taylor & Francis, 2011-11-01)
[Abstract] Asthenia-fatigue syndrome (AFS) is defined as a persistent, subjective sense of tiredness related to cancer or its treatment and greatly impacts quality of life among cancer patients. All tyrosine kinase inhibitors, ...
A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues
[Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ...