• Characterization of HMGB1/2 Interactome in Prostate Cancer by Yeast Two Hybrid Approach: Potential Pathobiological Implications 

      Barreiro-Alonso, Aida; Cámara-Quílez, María; Salamini-Montemurri, Martín; Lamas, Mónica; Vizoso-Vázquez, Ángel; Rodríguez-Belmonte, Esther; Quindós-Varela, María; Martínez-Iglesias, Olaia; Figueroa, Angélica; Cerdán, María Esperanza (MDPI, 2019-11-05)
      [Abstract] High mobility group box B (HMGB) proteins are pivotal in the development of cancer. Although the proteomics of prostate cancer (PCa) cells has been reported, the involvement of HMGB proteins and their interactome ...
    • Circulating microRNAs: molecular microsensors in gastrointestinal cancer 

      Blanco, Moisés; Calvo, Lourdes; Figueroa, Angélica; Haz, Mar; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (MPDI, 2012-07-09)
      [Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and ...
    • Circulating miR-200c and miR-141 and outcomes in patients with breast cancer 

      Antolín, Silvia; Calvo, Lourdes; Blanco, Moisés; Paz Santiago, María; Lorenzo-Patiño, María J.; Haz, Mar; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (BioMed Central, 2015)
      [Abstract] Background. The deregulation of microRNAs in both tumours and blood has led to the search for microRNAs to indicate the presence of cancer and predict prognosis. We hypothesize the deregulation of miR-200c/miR-141 ...
    • Clinical implications of epithelial cell plasticity in cancer progression 

      Antón-Aparicio, Luis M.; Blanco, Moisés; Castosa, Raquel; Concha, Ángel; Valladares-Ayerbes, Manuel; Calvo, Lourdes; Figueroa, Angélica (Elsevier, 2015)
      [Abstract] In the last few years, the role of epithelial cell plasticity in cancer biology research has gained increasing attention. This concept refers to the ability of the epithelial cells to dynamically switch between ...
    • Comprehensive lung injury pathology induced by mTOR inhibitors 

      Aparicio Gallego, Guadalupe; Medina, Vanessa; Fernández, Ovidio; Jiménez, Paula; Lema, Martina; Figueroa, Angélica; Antón-Aparicio, Luis M. (Springer para Federation of Spanish Oncology Sociesties (FESEO), 2009-08-29)
      [Abstract] Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation ...
    • Evaluation of Plakophilin-3 mRNA as a biomarker for detection of circulating tumor cells in gastrointestinal cancer patients 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina, Vanessa; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Pértega-Díaz, Sonia; Santamarina, Isabel; Blanco, Moisés; Quindós-Varela, María; Figueroa, Angélica; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2010-05-25)
      [Abstract] Background: This study aims to assess Plakophilin-3 (PKP3) as a surrogate biomarker of circulating tumor cells in patients with gastrointestinal cancer. Methods: The primary aim is to estimate the diagnostic ...
    • Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer 

      Valladares-Ayerbes, Manuel; Blanco, Moisés; Reboredo, Margarita; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Díaz-Prado, Silvia; Medina, Vanessa; Santamarina, Isabel; Pértega-Díaz, Sonia; Figueroa, Angélica; Antón-Aparicio, Luis M. (MDPI, 2012-04-05)
      [Abstract] We aim to estimate the diagnostic performances of anterior gradient homolog-2 (AGR2) and Leucine-rich repeat-containing-G-protein-coupled receptor 5 (LGR5) in peripheral blood (PB) as mRNA biomarkers in colorectal ...
    • Potential role of sugar transporters in cancer and their relationship with anticancer therapy 

      Blanco, Moisés; Figueroa, Angélica; Grande Pulido, Enrique; García Campelo, Rosario; Antón-Aparicio, Luis M. (Hindawi, 2010-06-20)
      [Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...
    • Prognostic impact of disseminated tumor cells and microRNA-17-92 cluster deregulation in gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Blanco, Moisés; Haz, Mar; Medina, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Reboredo, Margarita; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes (Spandidos, 2011-07-04)
      [Abstract] The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated ...
    • Role of the E3 Ubiquitin-Ligase Hakai in Intestinal Inflammation and Cancer Bowel Disease 

      Roca-Lema, Daniel; Quiroga, Macarena; Khare, Vineeta; Díaz-Díaz, Andrea; Barreiro-Alonso, Aida; Rodríguez-Alonso, Andrea; Concha, Ángel; Romay, Gabriela; Cerdán, María Esperanza; Gasche, Christoph; Figueroa, Angélica (Springer Nature, 2022-10-20)
      [Abstract] The E3 ubiquitin-ligases are important for cellular protein homeostasis and their deregulation is implicated in cancer. The E3 ubiquitin-ligase Hakai is involved in tumour progression and metastasis, through the ...