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Practical guidelines for diagnosis and treatment of acromegaly
(Elsevier, 2013-10)
[Abstract] Acromegaly and gigantism are due to excess GH secretion, usually by a pituitary adenoma. It is an uncommon disease.
Diagnosis is made by showing elevated GH and IGF-I levels in patients with a clinical picture ...
Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications
(Hindawi, 2010)
[Abstract] Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR). The first studies about role of ghrelin ...
Assessing motivational stages and processes of change for weight management around bariatric surgery: a multicenter study
(Springer Nature, 2019-06-17)
[Abstract] Introduction/purpose: The assessment of the patients' motivation as a predictor of behavioral change via five stages (pre-contemplation, contemplation, preparation, action, and maintenance) and four processes ...
Serum levels of the adipomyokine irisin in patients with chronic kidney disease
(Elsevier, 2016-12-14)
[Abstract] Background. Irisin is an adipomyokine with claimed anti-obesity and anti-diabetic effects. This hormone has been insufficiently studied in patients with advanced chronic kidney disease (CKD).
Objective. To ...
Treatment adherence to pegvisomant in patients with acromegaly in Spain: PEGASO study
(Springer, 2019-02-13)
[Abstract] PURPOSE: The burden of chronic daily subcutaneous administration of pegvisomant on adherence has not been previously studied. This study was aimed to determine the adherence to pegvisomant treatment in acromegaly ...
Treatment with growth hormone for adults with growth hormone deficiency syndrome: benefits and risks
(MDPI, 2018-03-17)
[Abstract] Pharmacological treatment of growth hormone deficiency (GHD) in adults began in clinical practice more than 20 years ago. Since then, a great volume of experience has been accumulated on its effects on the ...
Importance of exercise in the control of metabolic and inflammatory parameters at the moment of onset in type 1 diabetic subjects
(Thieme, 2014-05-05)
[Abstract] The onset of type 1 diabetes coincides with the final phase of β-cell destruction. In some cases, this period is characterized by the presence of a functional reserve of β-cells, favouring an adequate metabolic ...
Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism
(Elsevier, 2011)
[Abstract] Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated ...
Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
(Endocrine Society, 2013)
[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ...
Circulating levels of irisin in hypopituitary and normal subjects
(PLoS ONE, 2016-07-29)
[Abstract] Context. The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an ...