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Current Development of Alternative Treatments for Endothelial Decompensation: Cell-Based Therapy
(Elsevier, 2021-04-01)
[Abstract]
Current treatment for corneal endothelial dysfunction consists in the replacement of corneal endothelium by keratoplasty. Owing to the scarcity of donor corneas and the increasing number of transplants, alternative ...
Tips and Tricks for Successfully Culturing and Adapting Human Induced Pluripotent Stem Cells [Protocol]
(Cell Press, 2021-12)
[Abstract] Reprogramming somatic cells toward pluripotency became possible over a decade ago. Since then, induced pluripotent stem cells (iPSCs) have served as a versatile and powerful tool not only for basic research but ...
Analysis of Cryopreservation Protocols and Their Harmful Effects on the Endothelial Integrity of Human Corneas
(MDPI, 2021-11-22)
[Abstract] Corneal cryopreservation can partially solve the worldwide concern regarding donor cornea shortage for keratoplasties. In this study, human corneas were cryopreserved using two standard cryopreservation protocols ...
Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
(BioMed Central, 2012-08-12)
[Abstract]
Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ...
Differentiation of human mesenchymal stromal cells cultured on collagen sponges for cartilage repair
(Sociedad Española de Histología e Ingeniería Tisular, 2016)
[Abstract] Aim: The aim of this study was to evaluate proliferation and chondrogenic differentiation of human bone-marrow mesenchymal stromal cells (hBMSCs) cultured on collagen biomaterials.
Materials and methods: ...
Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential
(Hindawi, 2013-06-30)
[Abstract] Background. The interests in mesenchymal stem cells (MSCs) and their application in cell therapy have resulted in a better understanding of the basic biology of these cells. Recently hypoxia has been indicated ...
Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily
(Springer, 2014-09-10)
[Abstract] Mesenchymal stem cells (MSCs) are an accepted candidate for cell-based therapy of multiple diseases. The interest in MSCs and their possible application in cell therapy have resulted in a better understanding ...
Human amniotic membrane as an alternative source of stem cells for regenerative medicine
(Elsevier, 2011-02-19)
[Abstract] The human amniotic membrane (HAM) is a highly abundant and readily available tissue. This amniotic tissue has considerable advantageous characteristics to be considered as an attractive material in the field of ...
Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer
(MDPI, 2012-04-05)
[Abstract] We aim to estimate the diagnostic performances of anterior gradient homolog-2 (AGR2) and Leucine-rich repeat-containing-G-protein-coupled receptor 5 (LGR5) in peripheral blood (PB) as mRNA biomarkers in colorectal ...
Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias
(Elsevier, 2010-07-01)
[Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa.
Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression ...