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Usefulness of mesenchymal cell lines for bone and cartilage regeneration research
(MDPI, 2019-12-13)
[Abstract]
The unavailability of sufficient numbers of human primary cells is a major roadblock
for in vitro repair of bone and/or cartilage, and for performing disease modelling experiments.
Immortalized mesenchymal ...
Generation of mesenchymal cell lines derived from aged donors
(MDPI, 2021-10-01)
[Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...
Tips and Tricks for Successfully Culturing and Adapting Human Induced Pluripotent Stem Cells [Protocol]
(Cell Press, 2021-12)
[Abstract] Reprogramming somatic cells toward pluripotency became possible over a decade ago. Since then, induced pluripotent stem cells (iPSCs) have served as a versatile and powerful tool not only for basic research but ...
Ovine mesenchymal stromal cells: morphologic, phenotypic and functional characterization for osteochondral tissue engineering
(PLoS ONE, 2017-01-31)
[Abstract] Introduction. Knowledge of ovine mesenchymal stromal cells (oMSCs) is currently expanding. Tissue engineering combining scaffolding with oMSCs provides promising therapies for the treatment of osteochondral ...
Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
(BioMed Central, 2012-08-12)
[Abstract]
Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ...
Differentiation of human mesenchymal stromal cells cultured on collagen sponges for cartilage repair
(Sociedad Española de Histología e Ingeniería Tisular, 2016)
[Abstract] Aim: The aim of this study was to evaluate proliferation and chondrogenic differentiation of human bone-marrow mesenchymal stromal cells (hBMSCs) cultured on collagen biomaterials.
Materials and methods: ...
Effects of severe hypoxia on bone marrow mesenchymal stem cells differentiation potential
(Hindawi, 2013-06-30)
[Abstract] Background. The interests in mesenchymal stem cells (MSCs) and their application in cell therapy have resulted in a better understanding of the basic biology of these cells. Recently hypoxia has been indicated ...
Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily
(Springer, 2014-09-10)
[Abstract] Mesenchymal stem cells (MSCs) are an accepted candidate for cell-based therapy of multiple diseases. The interest in MSCs and their possible application in cell therapy have resulted in a better understanding ...
Human amniotic membrane as an alternative source of stem cells for regenerative medicine
(Elsevier, 2011-02-19)
[Abstract] The human amniotic membrane (HAM) is a highly abundant and readily available tissue. This amniotic tissue has considerable advantageous characteristics to be considered as an attractive material in the field of ...
Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects
(Mary Ann Liebert, 2011-03-22)
[Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine ...