Buscar
Mostrando ítems 11-20 de 23
miR-203 regulates cell proliferation through Its influence on Hakai expression
(PLoS, 2012-12-20)
Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational ...
Hakai reduces cell-substratum adhesion and increases epithelial cell invasion
(BioMed Central, 2011-11-03)
[Abstract]
Background. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the ...
Biological influence of Hakai in cancer: a 10-year review
(Springer, 2012-02-19)
[Abstract] In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the ...
Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer
(Future Science, 2014-06-20)
[Abstract] Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also ...
Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer
(BioMed Central, 2012-09-06)
[Abstract]
Background. MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates ...
Diagnosis delay and follow-up strategies in colorectal cancer. Prognosis implications: a study protocol
(BioMed Central, 2010-10-05)
[Abstract] Background: Controversy exists with regard to the impact that the different components of diagnosis delay may have on the degree of invasion and prognosis in patients with colorectal cancer. The follow-up ...
Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer
(Elsevier, 2008)
[Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...
Diagnostic accuracy of small breast epithelial mucin mRNA as a marker for bone marrow micrometastasis in breast cancer: a pilot study
(Springer-Verlag, 2009-02-17)
[Abstract] Background. Detection of isolated tumour cells (ITC) in the blood or minimal deposits in distant organs such as bone marrow (BM) could be important to identify breast cancer patients at high risk of relapse or ...
Tissue array analysis for the differentiation of gliosis from gliomas
(Spandidos, 2011-03-22)
[Abstract] The aim of this study was to provide a methodology to make a clear distinction between malignant tumors and morphologically similar benign processes, by examining the expression of EGFR, VEGF, HIF1-α, survivin, ...
Expression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomas
(Spirnger, 2009)
[Abstract] Genes of the Wnt and Frizzled class, expressed in HNSCC tissue and cell lines, have an established role in cell morphogenesis and differentiation, and also they have oncogenic properties. We studied Wnt and Fz ...