ListarInstituto de Investigación Biomédica da Coruña (INIBIC) por tema "Epigenetics"
Mostrando ítems 1-5 de 5
-
Epigenetics as a therapeutic target in osteoarthritis
(MDPI, 2023-01-21)[Abstract] Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered ... -
Is It Time for Epigenetics in Osteoarthritis?
(Wiley, 2014-05-16)[Abstract] DNA methylation is an epigenetic mechanism of reversible gene regulation which typically results in gene silencing upon hypermethylation in high CpG density regions of promoters (termed CpG islands), and increased ... -
Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis
(Elsevier, 2022-05-13)[Abstract] Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify ... -
Mitochondrial genetics and epigenetics in osteoarthritis
(Frontiers, 2020-01-17)[Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ... -
Specific premature epigenetic aging of cartilage in osteoarthritis
(Impact Journals, 2016-09-28)[Abstract] Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, ...
