ListarInstituto de Investigación Biomédica da Coruña (INIBIC) por tema "Aging"

Mostrando ítems 1-8 de 8

    • Association of torquetenovirus viremia with physical frailty and cognitive impairment in three independent european cohorts 

      Giacconi, Robertina; Laffon, Blanca; Costa, Solange; Teixeira-Gomes, Armanda; Maggi, Fabrizio; Macera, Lisa; Spezia, Pietro Giogio; Piacenza, Francesco; Bürkle, Alexander; Moreno-Villanueva, María; Bonassi, Stefano; Valdiglesias, Vanessa; Teixeira, Joao Paulo; Dollé, Martijn E.T.; Rietman, M. Liset; Jansen, Eugène; Grune, Tilman; Gonos, Efstathios S.; Franchesci, Claudio; Capri, Miriam; Weinberger, Birgit; Sikora, Ewa; Stuetz, Wolfgang; Toussaint, Olivier; Debacq-Chainiaux, Florence; Hervonen, Antti; Hurme, Mikko; Slagboom, P. Eline; Schön, Christiane; Bernhardt, Jürgen; Breusing, Nicolle; Pásaro, Eduardo; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Provinciali, Mauro; Malavolta, Marco (Karger, 2023-01-10)
      [Abstract] Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, ...

    • Clinical and neuropsychological correlates of prefrailty syndrome 

      Lorenzo-López, Laura; Blanco-Fandiño, J.; Cibeira, Nuria; Buján, Ana; López-López, Rocío; Maseda, Ana; Millán-Calenti, José Carlos (Frontiers Media S.A., 2020-11-09)
      [Abstract] Physical frailty is closely associated with cognitive impairment. We aim to investigate the neuropsychological profiles of prefrail and non-frail dementia-free community-dwelling older adults using a comprehensive ...

    • Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis 

      Lorenzo-Gómez, I.; Nogueira Recalde, Uxía; García-Domínguez, C.; Oreiro, Natividad; Lotz, Martin; Pinto-Tasende, José A.; Blanco García, Francisco J; Caramés, Beatriz (Elsevier, 2023-03-08)
      [Abstract] Objective: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA. Design: An autophagy-related ...

    • Development of new non-viral systems for genetic modification of senescent cells 

      López-Seijas, Junquera; Miranda-Balbuena, Diego; Iglesias-Fente, Alba; Sacristán-Santos, Marta; Carballo-Pedrares, Natalia; Arufe, M.C.; Rey-Rico, Ana; Fafián Labora, Juan Antonio (Cell Press, 2023-03-20)
      [Abstract] Senescence is a process characterized by a prolonged irreversible cell-cycle arrest. The accumulation of senescent cells in tissues is related to aging and to the development of age-related diseases. Recently, ...

    • Estudio fenomenológico sobre la relación entre el envejecimiento activo y la terapia ocupacional en centros de día y residencias de la ciudad de A Coruña 

      Carracedo Vázquez, Marta; Nieto-Riveiro, Laura; Miranda-Duro, María del Carmen; Groba, Betania; Pousada, Thais; Pereira-Loureiro, Javier (Universidad de Chile, 2017-06-30)
      [Resumen] Objetivos: El Envejecimiento Activo se centra en la participación de las personas mayores en los asuntos sociales, económicos, culturales, espirituales y cívicos, y no únicamente en la capacidad de estar activos ...

    • Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype 

      Del Rey, Manuel J.; Valín, Álvaro; Usategui, Alicia; Ergueta, Sandra; Martín, Eduardo; Municio, Cristina; Cañete, Juan D.; Blanco García, Francisco J; Criado, Gabriel; Pablos, José L. (BMC, 2019-11-05)
      [Abstract] Background Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence ...

    • Serum cortisol but not oxidative stress biomarkers are related to frailty: results of a cross-sectional study in Spanish older adults 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Taylor&Francis, 2019-08-13)
      [Abstract] Frailty is a multidimensional geriatric syndrome of loss of reserves and increased vulnerability to negative health outcomes. Cortisol, the major hormone of the hypothalamic pituitary adrenal (HPA) axis, and ...

    • Small extracellular vesicles have GST activity and ameliorate senescence-related tissue damage 

      Fafián Labora, Juan Antonio; Rodríguez-Navarro, José Antonio; O’Loghlen, Ana (Elsevier, 2020-07-07)
      [Abstract] Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ...