Listar Instituto de Investigación Biomédica da Coruña (INIBIC) por autor "Ramos-Louro, Paula"
Mostrando ítems 1-5 de 5
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Genetic biomarkers in osteoarthritis: a quick overview
Rego-Pérez, Ignacio; Durán Sotuela, Alejandro; Ramos-Louro, Paula; Blanco García, Francisco J (Faculty Opinions, 2021-11-10)[Abstract] Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature. In addition, when clinical manifestations appear, the evolution of the disease is usually already irreversible. ... -
Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes
Cortés-Pereira, Estefanía; Fernández-Tajes, Juan; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Relaño, Sara; Ramos-Louro, Paula; Durán-Sotuela, Alejandro; Dalmao-Fernández, Andrea; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2019-02-12)[Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage. Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ... -
Mitochondrial genetics and epigenetics in osteoarthritis
Rego-Pérez, Ignacio; Durán-Sotuela, Alejandro; Ramos-Louro, Paula; Blanco García, Francisco J (Frontiers, 2020-01-17)[Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ... -
mtDNA haplogroup A enhances the effect of obesity on the risk of knee OA in a mexican population
Ramos-Louro, Paula; Arellano Pérez Vertti, Rubén Daniel; López Reyes, Alberto; Martínez-Nava, Gabriela Angélica; Espinosa, Rolando; Pineda, Carlos; González-Galarza, Faviel Francisco; Argüello Astorga, Rafael; Aguilar Muñiz, Lizette Sarai; Hernández Terán, Fernando; Parra Torres, Nancy Marbella; Durán Sotuela, Alejandro; Fernández-Moreno, Mercedes; Balboa-Barreiro, Vanesa; Blanco García, Francisco J; Rego-Pérez, Ignacio (Nature, 2022-03-25)[Abstract] To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. Samples were obtained from (n = 353) knee OA patients ... -
Oleate prevents palmitate-induced mitochondrial dysfunction in chondrocytes
Vázquez-Mosquera, María E.; Fernández-Moreno, Mercedes; Cortés-Pereira, Estefanía; Relaño, Sara; Dalmao-Fernández, Andrea; Ramos-Louro, Paula; Durán Sotuela, Alejandro; Rego-Pérez, Ignacio; Blanco García, Francisco J (Frontiers, 2021-06-15)[Abstract] The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors ...