Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias
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Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakiasAutor(es)
Fecha
2010-07-01Cita bibliográfica
Díaz Prado S, López Cedrún JL, Luaces Rey R, Medina Villamil V, Álvarez García A, Valladares Ayerbes M, et al. Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias. Exp Mol Pathol. 2010;89(2):197-203.
Resumen
[Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa.
Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression of COX-2, EGFR and p53 in 24 biopsies of non-dysplastic oral leukoplakia and contra-lateral normal-appearing mucosa.
Results. COX-2 was up-regulated in leukoplakia (79.2%); whereas EGFR and p53 were up-regulated (p > 0.05) in oral contra-lateral normal-appearing mucosa (60% and 46% respectively). Also, p53 expression was correlated with tobacco smoke habits and Spearman's rank correlation coefficient showed a positive linear correlation between p53 and EGFR mRNA expression levels.
Conclusions. COX-2 would serve as SEB of oral leukoplakia. The results suggest that p53 appears to be one of the molecular targets of tobacco-related carcinogens in leukoplakia and that the co-expression of p53 and EGFR may play a role in this kind of oral pre-cancerous lesion. More detailed studies of EGFR and p53 should be continued in the future.
Palabras clave
EGFR
COX-2
p53
Oral leukoplakia
Quantitative real-time PCR
Molecular marker
COX-2
p53
Oral leukoplakia
Quantitative real-time PCR
Molecular marker
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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International Licence (CC-BY-NC-ND 4.0)