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Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
(MDPI, 2023-07-19)
[Abstract] Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biodegradable and biocompatible biopolymer that has gained popularity in the field of biomedicine. This review provides an overview of recent advances and ...
Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features
(Hindawi, 2020-06-16)
[Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ...
Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview
(MDPI, 2020-08-10)
[Abstract]
Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various
regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular,
or neural tissues disorders ...
Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseases
(MDPI, 2020-08-25)
[Abstract]
Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells
capable of di erentiating into any cell type of the body. Several studies have demonstrated the valuable
use of iPSCs ...
Generation and Characterization of Human Induced Pluripotent Stem Cells (iPSCs) From Hand Osteoarthritis Patient-Derived Fibroblasts
(Nature Research, 2020-03-06)
[Abstract]
Knowledge and research results about hand osteoarthritis (hOA) are limited due to the lack of samples and animal models of the disease. Here, we report the generation of two induced pluripotent stem cell ...
Generation of a human control iPS cell line (ESi080‐A) from a donor with no rheumatic diseases
(Elsevier, 2020-03)
[Abstract]
Here, we report the establishment of the human iPS cell line N1-FiPS4F#7 generated from skin cells of a patient with no rheumatic diseases, thus obtaining an appropriate control iPS cell line for researchers ...
Mesenchymal stem cell therapy in traumatic spinal cord injury: a systematic review
(MDPI, 2023-07-20)
[Abstract] Recovery from a traumatic spinal cord injury (TSCI) is challenging due to the limited regenerative capacity of the central nervous system to restore cells, myelin, and neural connections. Cell therapy, particularly ...
Current Development of Alternative Treatments for Endothelial Decompensation: Cell-Based Therapy
(Elsevier, 2021-04-01)
[Abstract]
Current treatment for corneal endothelial dysfunction consists in the replacement of corneal endothelium by keratoplasty. Owing to the scarcity of donor corneas and the increasing number of transplants, alternative ...
Generation of mesenchymal cell lines derived from aged donors
(MDPI, 2021-10-01)
[Abstract] Background: Mesenchymal stromal cells (MSCs) have the capacity for self-renewal and multi-differentiation, and for this reason they are considered a potential cellular source in regenerative medicine of cartilage ...
Chondrogenic differentiation of human mesenchymal stem cells via SOX9 delivery in cationic niosomes
(MDPI, 2022-10-28)
[Abstract] Gene transfer to mesenchymal stem cells constitutes a powerful approach to promote their differentiation into the appropriate cartilage phenotype. Although viral vectors represent gold standard vehicles, because ...