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Specific roles of NMDA and AMPA receptors in direction-selective and spatial phase-selective responses in visual cortex
dc.contributor.author | Rivadulla, Casto | |
dc.contributor.author | Sharma, Jitendra | |
dc.contributor.author | Sur, Mriganka | |
dc.date.accessioned | 2015-05-25T11:12:14Z | |
dc.date.available | 2015-05-25T11:12:14Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Rivadulla C, Sharma J, Sur M. Specific roles of NMDA and AMPA receptors in direction-selective and spatial phase-selective responses in visual cortex. J Neurosci. 2001;21(5):1710-19. | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/14581 | |
dc.description.abstract | [Abstract] Cells in the superficial layers of primary visual cortex (area 17) are distinguished by feedforward input from thalamic-recipient layers and by massive recurrent excitatory connections be- tween neighboring cells. The connections use glutamate as transmitter, and the postsynaptic cells contain both NMDA and AMPA receptors. The possible role of these receptor types in generating emergent responses of neurons in the superficial cortical layers is unknown. Here, we show that NMDA and AMPA receptors are both involved in the generation of direction-selective responses in layer 2/3 cells of area 17 in cats. NMDA receptors contribute prominently to responses in the preferred direction, and their contribution to responses in the nonpreferred direction is reduced significantly by GABAer- gic inhibition. AMPA receptors decrease spatial phase-selective simple cell responses and generate phase-invariant complex cell respons | es_ES |
dc.description.sponsorship | This work was supported by National Institutes of Health Grants EY07023 and NS39022 to M.S. and by a Fulbright-MEC Fellowship from Spain to C.R | es_ES |
dc.description.sponsorship | National Institutes of Health (United States); EY07023 | |
dc.language.iso | eng | es_ES |
dc.publisher | Society of Neuroscience | es_ES |
dc.relation.uri | http://www.jneurosci.org/content/21/5/1710.short | es_ES |
dc.rights | Creative Coomons Attrribution 4.0 International Licence (CC-BY 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Cat primary visual cortex | es_ES |
dc.subject | Glutamate receptors | es_ES |
dc.subject | Cortical networks | es_ES |
dc.subject | Emergent responses | es_ES |
dc.subject | Feedforward connections | es_ES |
dc.subject | Recurrent connections | es_ES |
dc.title | Specific roles of NMDA and AMPA receptors in direction-selective and spatial phase-selective responses in visual cortex | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
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