Specific roles of NMDA and AMPA receptors in direction-selective and spatial phase-selective responses in visual cortex
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Specific roles of NMDA and AMPA receptors in direction-selective and spatial phase-selective responses in visual cortexData
2001Cita bibliográfica
Rivadulla C, Sharma J, Sur M. Specific roles of NMDA and AMPA receptors in direction-selective and spatial phase-selective responses in visual cortex. J Neurosci. 2001;21(5):1710-19.
Resumo
[Abstract] Cells in the superficial layers of primary visual cortex (area 17)
are distinguished by feedforward input from thalamic-recipient
layers and by massive recurrent excitatory connections be-
tween neighboring cells. The connections use glutamate as
transmitter, and the postsynaptic cells contain both NMDA and
AMPA receptors. The possible role of these receptor types in
generating emergent responses of neurons in the superficial
cortical layers is unknown. Here, we show that NMDA and
AMPA receptors are both involved in the generation of
direction-selective responses in layer 2/3 cells of area 17 in
cats. NMDA receptors contribute prominently to responses in
the preferred direction, and their contribution to responses in
the nonpreferred direction is reduced significantly by GABAer-
gic inhibition. AMPA receptors decrease spatial phase-selective
simple cell responses and generate phase-invariant complex
cell respons
Palabras chave
Cat primary visual cortex
Glutamate receptors
Cortical networks
Emergent responses
Feedforward connections
Recurrent connections
Glutamate receptors
Cortical networks
Emergent responses
Feedforward connections
Recurrent connections
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Creative Coomons Attrribution 4.0 International Licence (CC-BY 4.0)