Different sources of nitric oxide mediate neurovascular coupling in the lateral geniculate nucleus of the cat
![Thumbnail](/dspace/bitstream/handle/2183/14510/Labra_DifferentSources.pdf.jpg?sequence=4&isAllowed=y)
View/ Open
Use this link to cite
http://hdl.handle.net/2183/14510Collections
- GI-NEURO - Artigos [163]
- INIBIC-NEURO - Artigos [48]
Metadata
Show full item recordTitle
Different sources of nitric oxide mediate neurovascular coupling in the lateral geniculate nucleus of the catAuthor(s)
Date
2009-09-08Citation
Labra C de, Rivadulla C, Espinosa N, Dasilva M, Cao R, Cudeiro J. Different sources of nitric oxide mediate neurovascular coupling in the lateral geniculate nucleus of the cat. Front Syst Neurosci. 2009;3(9):1-9.
Abstract
[Abstract] Understanding the link between neuronal responses (NRs) and metabolic signals is fundamental to our knowledge of brain function and it is a milestone in our efforts to interpret data from modern non invasive optical techniques such as fMRI, which are based on the close coupling between metabolic demand of active neurons and local changes in blood flow. The challenge is to unravel the link. Here we show, using spectrophotometry to record oxyhaemoglobin and methemoglobin (surrogate markers of cerebral flow and nitric oxide levels respectively) together with extracellular neuronal recordings in vivo and applying a multiple polynomial regression model, that the markers are able to predict up about 80% of variability in NR. Furthermore, we show that the coupling between blood flow and neuronal activity is heavily influenced by nitric oxide (NO). While NRs show the typical saturating response, blood flow shows a linear behaviour during contrast-response curves, with nitric oxide from different sources acting differently for low and high intensity.
Keywords
LGN
Visual activity
NO
Neurovascular
Haemoglobin
Visual activity
NO
Neurovascular
Haemoglobin