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dc.contributor.authorLabra, Carmen de
dc.contributor.authorRivadulla, Casto
dc.contributor.authorEspinosa, Nelson
dc.contributor.authorDasilva, Miguel
dc.contributor.authorCao, Ricardo
dc.contributor.authorCudeiro, Javier
dc.date.accessioned2015-05-14T08:42:43Z
dc.date.available2015-05-14T08:42:43Z
dc.date.issued2009-09-08
dc.identifier.citationLabra C de, Rivadulla C, Espinosa N, Dasilva M, Cao R, Cudeiro J. Different sources of nitric oxide mediate neurovascular coupling in the lateral geniculate nucleus of the cat. Front Syst Neurosci. 2009;3(9):1-9.es_ES
dc.identifier.urihttp://hdl.handle.net/2183/14510
dc.description.abstract[Abstract] Understanding the link between neuronal responses (NRs) and metabolic signals is fundamental to our knowledge of brain function and it is a milestone in our efforts to interpret data from modern non invasive optical techniques such as fMRI, which are based on the close coupling between metabolic demand of active neurons and local changes in blood flow. The challenge is to unravel the link. Here we show, using spectrophotometry to record oxyhaemoglobin and methemoglobin (surrogate markers of cerebral flow and nitric oxide levels respectively) together with extracellular neuronal recordings in vivo and applying a multiple polynomial regression model, that the markers are able to predict up about 80% of variability in NR. Furthermore, we show that the coupling between blood flow and neuronal activity is heavily influenced by nitric oxide (NO). While NRs show the typical saturating response, blood flow shows a linear behaviour during contrast-response curves, with nitric oxide from different sources acting differently for low and high intensity.es_ES
dc.description.sponsorshipSupported by MEC (BFU2005-00502) and Xunta de Galicia (Consellería de Educación-2007/000140-0), Spain.es_ES
dc.description.sponsorshipMinisterio de Educación y Ciencia (España); BFU2005-00502
dc.language.isoenges_ES
dc.publisherFrontierses_ES
dc.relation.urihttp://dx.doi.org/10.3389/neuro.06.009.2009es_ES
dc.subjectLGNes_ES
dc.subjectVisual activityes_ES
dc.subjectNOes_ES
dc.subjectNeurovasculares_ES
dc.subjectHaemoglobines_ES
dc.titleDifferent sources of nitric oxide mediate neurovascular coupling in the lateral geniculate nucleus of the cates_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES


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