Browsing by Author "Valencia, Laura"

Now showing items 1-15 of 15

    • Developing the family of picolinate ligands for Mn2+ complexation 

      Forgács, Attila; Pujales-Paradela, Rosa; Regueiro-Figueroa, Martín; Valencia, Laura; Esteban-Gómez, David; Botta, Mauro; Platas-Iglesias, Carlos (Royal Society of Chemistry, 2016-12-22)
      [Abstract] We have reported here a series of ligands containing pentadentate 6,6′-(azanediylbis(methylene))dipicolinic acid units that differ in the substituent present at the amine nitrogen atom (acetate: H3DPAAA; phenyl: ...

    • Effect of Magnetic Anisotropy on the 1H NMR Paramagnetic Shifts and Relaxation Rates of Small Dysprosium(III) Complexes 

      Harriswangler, Charlene; Lucio Martínez, Fátima; Godec, Léna; Soro, Lohona K.; Fernández-Fariña, Sandra; Valencia, Laura; Rodríguez-Rodríguez, Aurora; Esteban-Gómez, David; Charbonnière, Loïc J.; Platas-Iglesias, Carlos (American Chemical Society, 2023-08-21)
      [Abstract]: We present a detailed analysis of the 1H NMR chemical shifts and transverse relaxation rates of three small Dy(III) complexes having different symmetries (C3, D2 or C2). The complexes show sizeable emission in ...

    • Endeavor toward Redox-Responsive Transition Metal Contrast Agents Based on the Cross-Bridge Cyclam Platform 

      Uzal-Varela, Rocío; Rodríguez-Rodríguez, Aurora; Lalli, Daniela; Valencia, Laura; Maneiro, Marcelino; Botta, Mauro; Iglesias, Emilia; Esteban-Gómez, David; Angelovski, Goran; Platas-Iglesias, Carlos (American Chemical Society, 2024-01-10)
      [Abstract]: We present the synthesis and characterization of a series of Mn(III), Co(III), and Ni(II) complexes with cross-bridge cyclam derivatives (CB-cyclam = 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane) containing acetamide ...

    • Exceptionally inert lanthanide(III) PARACEST MRI contrast agents based on an 18-membered macrocyclic platform 

      Castro, Goretti; Regueiro-Figueroa, Martín; Esteban-Gómez, David; Bastida, Rufina; Macías, Alejandro; Pérez-Lourido, Paulo; Platas-Iglesias, Carlos; Valencia, Laura (Wiley, 2015-12-14)
      [Abstract] We report a macrocyclic ligand based on a 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane platform containing four hydroxyethyl pendant arms (L1) that forms extraordinary inert complexes with Ln3+ ions. ...

    • Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(II)-based radiopharmaceuticals 

      Harriswangler, Charlene; McNeil, Brooke L.; Brandariz, Isabel; Lucio Martínez, Fátima; Valencia, Laura; Esteban-Gómez, David; Ramogida, Caterina; Platas-Iglesias, Carlos (Frontiers Journal portfolio (Chinese Chemical Society, Royal Society of Chemistry), 2023-12-28)
      [Abstract]: We report a detailed investigation on the use of chelators PYTAM, H4PYTAMGly, CHX-PYTAM and H4CHX-PYTAMGly for the complexation of Pb(II)-radioisotopes with potential use in the preparation of radiopharmaceuticals. ...

    • Incorporation of Carboxylate Pendant Arms into 18-Membered Macrocycles: Effects on [nat/203Pb]Pb(II) Complexation 

      Harriswangler, Charlene; McNeil, Brooke L.; Brandariz, Isabel; Valencia, Laura; Esteban-Gómez, David; Ramogida, Caterina; Platas-Iglesias, Carlos (Wiley-VCH, 2024-03-11)
      [Abstract]: We present a detailed investigation on the coordination chemistry of [nat/203Pb]Pb(II) with chelators H4PYTA and H4CHX-PYTA. These chelators belong to the family of ligands derived from the 18-membered macrocyclic ...

    • Inert macrocyclic Eu3+ complex with affirmative paraCEST features 

      Gambino, Tanja; Valencia, Laura; Pérez-Lourido, Paulo; Esteban-Gómez, David; Zaiss, Moritz; Platas-Iglesias, Carlos; Angelovski, Goran (Royal Society of Chemistry, 2020-06-21)
      [Abstract]: We report on a macrocyclic platform based on an 18-membered macrocycle that forms kinetically highly inert paramagnetic complexes and possesses an excellent outlook for the development of bioresponsive paraCEST ...

    • Magnetic anisotropies in rhombic lanthanide(III) complexes do not conform to Bleaney’s theory 

      Castro, Goretti; Regueiro-Figueroa, Martín; Esteban-Gómez, David; Pérez-Lourido, Paulo; Platas-Iglesias, Carlos; Valencia, Laura (American Chemical Society, 2016-04-04)
      [Abstract] We report a complete set of magnetic susceptibilities of lanthanide complexes with a macrocyclic ligand based on a 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane platform containing four hydroxyethyl ...

    • On the Dissociation Pathways of Copper Complexes Relevant as Pet Imaging Agents 

      Uzal-Varela, Rocío; Patinec, Véronique; Tripier, Raphaël; Valencia, Laura; Maneiro, Marcelino; Canle, Moisés; Platas-Iglesias, Carlos; Esteban-Gómez, David; Iglesias, Emilia (Elsevier, 2022)
      [Abstract] Several bifunctional chelators have been synthesized in the last years for the development of new 64Cu-based PET agents for in vivo imaging. When designing a metal-based PET probe, it is important to achieve ...

    • Synthesis and Structural Analysis of Push-Pull Imidazole-Triazole Based Fluorescent Bifunctional Chemosensor for CU2+ and FE2+ Detection 

      Da Lama Vázquez, Ana; Pérez Sestelo, José; Valencia, Laura; Esteban-Gómez, David; Sarandeses, Luis A.; Martínez, Montserrat (Elsevier, 2022-07)
      [Abstract] Fluorescent imidazole-triazole based ligands L1 and L2 have been designed as chemical push-pull chemosensors for divalent metal ions and synthesized through palladium-catalyzed cross-coupling reactions using ...

    • The relationship between NMR chemical shifts of thermally polarized and hyperpolarized 89Y complexes and their solution structures 

      Xing, Yixun; Jindal, Ashish K.; Regueiro-Figueroa, Martín; Le Fur, Mariane; Kervarec, Nelly; Zhao, Piyu; Kovacs, Zoltan; Valencia, Laura; Pérez-Lourido, Paulo; Tripier, Raphaël; Esteban-Gómez, David; Platas-Iglesias, Carlos; Sherry, A. Dean (Wiley, 2016-11-07)
      [Abstract] Recently developed dynamic nuclear polarization (DNP) technology offers the potential of increasing the NMR sensitivity of even rare nuclei for biological imaging applications. Hyperpolarized 89Y is an ideal ...

    • The role of ligand to metal charge-transfer states on the luminescence of Europium complexes with 18-membered macrocyclic ligands 

      Nonat, Aline; Esteban-Gómez, David; Valencia, Laura; Pérez-Lourido, Paulo; Barriada, José Luis; Charbonnière, Loïc J.; Platas-Iglesias, Carlos (Royal Society of Chemistry, 2019-02-27)
      [Abstract] We report a detailed study of the photophysical properties of EuIII and TbIII complexes with two ligands based on a 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane platform containing either four ...

    • Thermodynamic Stability of Mn(II) Complexes with Aminocarboxylate Ligands Analyzed Using Structural Descriptors 

      Uzal-Varela, Rocío; Pérez-Fernández, Francisco; Valencia, Laura; Rodríguez-Rodríguez, Aurora; Platas-Iglesias, Carlos; Caravan, Peter; Esteban-Gómez, David (ACS, 2022-08-22)
      [Abstract] We present a quantitative analysis of the thermodynamic stabilities of Mn(II) complexes, defined by the equilibrium constants (log KMnL values) and the values of pMn obtained as −log[Mn]free for total metal and ...

    • Understanding the Effect of the Electron Spin Relaxation on the Relaxivities of Mn(II) Complexes with Triazacyclononane Derivatives 

      Uzal-Varela, Rocío; Valencia, Laura; Lalli, Daniela; Maneiro, Marcelino; Esteban-Gómez, David; Platas-Iglesias, Carlos; Botta, Mauro; Rodríguez-Rodríguez, Aurora (American Chemical Society, 2021-10-07)
      [Abstract] Investigating the relaxation of water ¹H nuclei induced by paramagnetic Mn(II) complexes is important to understand the mechanisms that control the efficiency of contrast agents used in diagnostic magnetic ...

    • Versatile Macrocyclic Platform for the Complexation of [ⁿᵃᵗY/⁹⁰Y]Yttrium and Lanthanide Ions 

      Harriswangler, Charlene; Caneda-Martínez, Laura; Rousseaux, Olivier; Esteban-Gómez, David; Fougère, Olivier; Pujales-Paradela, Rosa; Valencia, Laura; Fernández-Pérez, María-Isabel; Lepareur, Nicolas; Platas-Iglesias, Carlos (American Chemical Society, 2022-04-14)
      [Abstract] We report a macrocyclic ligand (H3L6) based on a 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane platform containing three acetate pendant arms and a benzyl group attached to the fourth nitrogen atom ...