Now showing items 1-20 of 58

    • Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily 

      Cicione, Claudia; Muiños Gómez, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Springer, 2014-09-10)
      [Abstract] Mesenchymal stem cells (MSCs) are an accepted candidate for cell-based therapy of multiple diseases. The interest in MSCs and their possible application in cell therapy have resulted in a better understanding ...
    • An artificial-vision- and statistical-learning-based method for studying the biodegradation of type I collagen scaffolds in bone regeneration systems 

      Robles-Bykbaev, Yaroslava; Naya, Salvador; Díaz-Prado, Silvia; Calle-López, D.; Robles-Bykbaev, Vladimir; Garzón, Luis; Sanjurjo-Rodríguez, Clara; Tarrío-Saavedra, Javier (PeerJ, 2019-07-05)
      [Abstract] This work proposes a method based on image analysis and machine and statistical learning to model and estimate osteocyte growth (in type I collagen scaffolds for bone regeneration systems) and the collagen ...
    • An educational environment based on digital image processing to support the learning process of biomaterials degradation in stem cells 

      Robles-Bykbaev, Yaroslava; Naya, Salvador; Tarrío-Saavedra, Javier; Díaz-Prado, Silvia; Sanjurjo-Rodríguez, Clara; Blanco García, Francisco J; Cornejo-Reyes, J.; Garzón, Luis; Calle-López, D. (IEEE, 2018-11-08)
      [Abstract] The Poly(DL-lactide-co-glycolide) copolymers (PDLGA) have designed and performed as biomaterials, taking into account their biodegradability and biocompatibility properties. These materials have a wide range of ...
    • Analysis of cryopreservation protocols and their harmful effects on the endothelial integrity of human corneas 

      Rodríguez-Fernández, Silvia; Álvarez-Portela, Marcelino; Rendal Vázquez, María Esther; Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Sánchez-Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (MDPI, 2021-11-22)
      [Abstract] Corneal cryopreservation can partially solve the worldwide concern regarding donor cornea shortage for keratoplasties. In this study, human corneas were cryopreserved using two standard cryopreservation protocols ...
    • Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; García Campelo, Rosario; Haz, Mar; Santamarina, Isabel; Antón-Aparicio, Luis M. (Elsevier, 2008)
      [Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...
    • Biology of BMP signalling and cancer 

      Blanco, Moisés; Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)
      [Abstract] In recent years, it has been proposed that tumours are not homogeneous but composed of several cellular types like normal tissues. A cellular subtype, which is though to be the origin of tumours as well as their ...
    • Bone marrow cells immunomagnetically selected for CD271+ antigen promote in vitro the repair of articular cartilage defects 

      Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Gimeno-Longas, María José; Muíños-López, Emma; Díaz-Prado, Silvia; Toro Santos, Francisco Javier de; Blanco García, Francisco J (Mary Ann Liebert, 2011-03-22)
      [Abstract] Objective: The purposes of this project were to quantify the cells expressing the mesenchymal stem cell (MSC) marker CD271 in synovial membranes from human osteoarthritic (OA) and healthy joints, and to determine ...
    • Cartilage tissue engineering: adult human mesenchymal stromal cells and collagen biomaterials 

      Sanjurjo-Rodríguez, Clara; Martínez Sánchez, A.H.; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Buján, J.; Toro Santos, Francisco Javier de; Díaz-Prado, Silvia; Blanco García, Francisco J (Elsevier, 2014-03-20)
    • Cell and Tissue Transplant Strategies for Joint Lesions 

      Fuentes Boquete, Isaac Manuel; Arufe, M.C.; Díaz-Prado, Silvia; Hermida Gómez, Tamara; Toro Santos, Francisco Javier de; Blanco García, Francisco J (Bentham Open, 2008-07-11)
      [Abstract] Articular cartilage lesions that do not disrupt the integrity of subchondral bone are not capable of spontaneous repair. The asymptomatic nature of these lesions leads to articular cartilage degeneration and ...
    • Cell therapy and tissue engineering for cartilage repair 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Toro Santos, Francisco Javier de; Blanco García, Francisco J; Díaz-Prado, Silvia (IntechOpen, 2018-02-14)
      [Abstract] The integrity of the articular cartilage is necessary for the proper functioning of the diarthrodial joint. The self-repair capacity of this tissue is very limited and, currently, there is no effective treatment ...
    • Cell viability assay in corneal endothelium 

      Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2018)
      [Abstract] Introduction: Endothelium is the inner layer of the cornea, which must be viable for transplanting. The limited availability of corneas makes necessary the developing of preservation ...
    • Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes 

      Díaz-Prado, Silvia; Cicione, Claudia; Muiños-López, Emma; Hermida Gómez, Tamara; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2012-08-12)
      [Abstract] Background. Osteoarthritis (OA) is a multifactorial disease characterized by destruction of the articular cartilage due to environmental, mechanical and genetic components. The genetics of OA is complex and ...
    • La ciclooxigenasa-2 (COX-2) y el factor de crecimiento epidérmico (EFG) en lesiones epiteliales orales premalignas 

      Díaz-Prado, Silvia; Antón-Aparicio, Luis M.; Gallego Guadalupe, A.; López-Cedrún Cembranos, José Luis; Ferreras Granado, José (Sociedad Española de Cirugía Oral y Maxilofacial (SECOM), 2009)
      [Resumen] Las lesiones premalignas orales incluyen eritroplasias (manchas rojas) y leucoplasias (manchas blancas), las cuales se desarrollan a lo largo de superficies epiteliales. Estas lesiones son considerados marcadores ...
    • Corneal cryopreservation: and endothelial cell viability and histomorphological study of cornea 

      Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2019)
    • Criopreservación de córnea: estudio de la viabilidad celular endotelial y de la histomofología de la córnea 

      Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2019)
    • Cryopreservation effect on proliferative and chondrogenic potential of human chondrocytes isolated from superficial and deep cartilage 

      Muíños López, Emma; Rendal Vázquez, María Esther; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Blanco García, Francisco J (Bentham Open, 2012-04-06)
      [Abstract] Objectives: To compare the proliferative and chondrogenic potential of fresh and frozen chondrocytes isolated from superficial and deep articular cartilage biopsies. Materials and Methodology: The study ...
    • Current Development of Alternative Treatments for Endothelial Decompensation: Cell-Based Therapy 

      Rodríguez-Fernández, Silvia; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Álvarez Portela, Marcelino; Fuentes Boquete, Isaac Manuel; Rendal Vázquez, María Esther; Díaz-Prado, Silvia (Elsevier, 2021-04-01)
      [Abstract] Current treatment for corneal endothelial dysfunction consists in the replacement of corneal endothelium by keratoplasty. Owing to the scarcity of donor corneas and the increasing number of transplants, alternative ...
    • Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer 

      Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Jiménez Fonseca, P.; García Campelo, Rosario; Casinello Espinosa, J.; Antón-Aparicio, Luis M. (Springer, 2007-12-15)
      [Abstract] Epidemiological studies provided the first evidence that COX may be involved in the pathogenesis of cancer. In the process of carcinogenesis and in the route of intracellular signalling during carcinogenesis, ...
    • Detección de la viabilidad celular sobre endotelio corneal 

      Rodríguez-Fernández, Silvia; Álvarez Portela, Marcelino; Rendal Vázquez, María Esther; Montero Salinas, Alejandro; Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Rojas, María Victoria de; Sánchez Ibáñez, Jacinto; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (2018)
    • Diagnostic accuracy of small breast epithelial mucin mRNA as a marker for bone marrow micrometastasis in breast cancer: a pilot study 

      Valladares-Ayerbes, Manuel; Iglesias-Díaz, Pilar; Díaz-Prado, Silvia; Ayude, Daniel; Medina Villaamil, Vanessa; Haz, Mar; Reboredo, Margarita; Antolín, Silvia; Calvo, Lourdes; Antón-Aparicio, Luis M. (Springer-Verlag, 2009-02-17)
      [Abstract] Background. Detection of isolated tumour cells (ITC) in the blood or minimal deposits in distant organs such as bone marrow (BM) could be important to identify breast cancer patients at high risk of relapse or ...