Listar por autor "Rego-Pérez, Ignacio"

Mostrando ítems 21-40 de 41

    • Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes 

      Cortés-Pereira, Estefanía; Fernández-Tajes, Juan; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Relaño, Sara; Ramos-Louro, Paula; Durán-Sotuela, Alejandro; Dalmao-Fernández, Andrea; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2019-02-12)
      [Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage. Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ...

    • Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids 

      Dalmao-Fernández, Andrea; Hermida Gómez, Tamara; Lund, Jenny; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Garesse, Rafael; Blanco García, Francisco J; Fernández-Moreno, Mercedes (Elsevier, 2022-05)
      [Abstract] With the redefinition of osteoarthritis (OA) and the understanding that the joint behaves as an organ, OA is now considered a systemic illness with a low grade of chronic inflammation. Mitochondrial dysfunction ...

    • Mitochondrial DNA haplogroup H as a risk factor for idiopathic dilated cardiomyopathy in Spanish population 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (Elsevier, 2013-03-23)
      [Abstract] Idiopathic dilated cardiomyopathy (IDC) is a structural heart disease with strong genetic background. The different single nucleotide polymorphisms (SNPs) that constitute mitochondrial haplogroups could play an ...

    • Mitochondrial DNA haplogroups associated with MRI-detected structural damage in early knee osteoarthritis 

      Rego-Pérez, Ignacio; Blanco García, Francisco J; Roemer, Frank W.; Guermazi, Ali; Ran, Di; Ashbeck, Erin L.; Fernández Moreno, Mercedes; Oreiro, Natividad; Hannon, Michael J.; Hunter, David J.; Kwoh, Kent (Elsevier, 2018-07-20)
      [Abstract] Objective: Magnetic resonance imaging (MRI)-detected structural features are associated with increased risk of radiographic osteoarthritis (ROA). Specific mitochondrial DNA (mtDNA) haplogroups have been associated ...

    • Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta-analysis and functional study 

      Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Vázquez-Mosquera, María E.; Cortés-Pereira, Estefanía; Relaño, Sara; Hermida Gómez, Tamara; Pértega-Díaz, Sonia; Oreiro, Natividad; Fernández-López, Carlos; Garesse, Rafael; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2016-12-05)
      [Abstract] Objective To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential ...

    • Mitochondrial DNA Impact on Joint Damaged Process in a Conplastic Mouse Model After Being Surgically Induced With Osteoarthritis 

      Scotece, Morena; Rego-Pérez, Ignacio; Lechuga-Vieco, Ana Victoria; Centeno, Alberto; Jiménez-Gómez, María Concepción; Filgueira-Fernández, P.; Vaamonde-García, Carlos; Enríquez, José Antonio; Blanco García, Francisco J (Nature, 2021-04-27)
      [Abstract] It has been suggested that mitochondrial dysfunction and mtDNA variations may contribute to osteoarthritis (OA) pathogenesis. However, the causative link to support this claim is lacking. Here, we surgically-induced ...

    • Mitochondrial DNA in Osteoarthritis Disease 

      Blanco García, Francisco J; Rego-Pérez, Ignacio (Springer, 2020-09-25)
      [Abstract] Osteoarthritis (OA) is the most prevalent chronic joint disease, and we actually know that the activation of maladaptive responses to injury, including pro-inflammatory pathways, leads to the loss of normal ...

    • Mitochondrial genetics and epigenetics in osteoarthritis 

      Rego-Pérez, Ignacio; Durán-Sotuela, Alejandro; Ramos-Louro, Paula; Blanco García, Francisco J (Frontiers, 2020-01-17)
      [Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ...

    • Mitochondrial haplogroups define two phenotypes of osteoarthritis 

      Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Oreiro, Natividad; Pértega-Díaz, Sonia; Fernández-López, Carlos; Rego-Pérez, Ignacio; Blanco García, Francisco J (Frontiers, 2012-05-11)
      [Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA). Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ...

    • Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy 

      Fernández Caggiano, Mariana; Barallobre-Barreiro, Javier; Rego-Pérez, Ignacio; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Grille Cancela, Zulaika; Blanco García, Francisco J; Doménech, Nieves (PLoS, 2012-08-28)
      [Abstract] Background. Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may ...

    • Mitochondrial Respiratory Chain Dysfunction Modulates Metalloproteases -1, -3 and -13 in Human Normal Chondrocytes in Culture 

      Cillero-Pastor, B.; Rego-Pérez, Ignacio; Oreiro, Natividad; Fernández-López, Carlos; Blanco García, Francisco J (BioMed Central, 2013-08-09)
      [Abstract] Background. Mitochondrion has an important role in the osteoarthritis (OA) pathology. We have previously demonstrated that the alteration of the mitochondrial respiratory chain (MRC) contributes to the inflammatory ...

    • mtDNA haplogroup A enhances the effect of obesity on the risk of knee OA in a mexican population 

      Ramos-Louro, Paula; Arellano Pérez Vertti, Rubén Daniel; López Reyes, Alberto; Martínez-Nava, Gabriela Angélica; Espinosa, Rolando; Pineda, Carlos; González-Galarza, Faviel Francisco; Argüello Astorga, Rafael; Aguilar Muñiz, Lizette Sarai; Hernández Terán, Fernando; Parra Torres, Nancy Marbella; Durán Sotuela, Alejandro; Fernández-Moreno, Mercedes; Balboa-Barreiro, Vanesa; Blanco García, Francisco J; Rego-Pérez, Ignacio (Nature, 2022-03-25)
      [Abstract] To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. Samples were obtained from (n = 353) knee OA patients ...

    • mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model 

      Scotece, Morena; Vaamonde-García, Carlos; Lechuga-Vieco, Ana Victoria; Centeno Cortés, Alberto; Jiménez Gómez, María Concepción; Filgueira-Fernández, Purificación; Rego-Pérez, Ignacio; Enríquez, José Antonio; Blanco García, Francisco J (Impact Journals, 2022-07-02)
      [Abstract] Mitochondria and mtDNA variations contribute to specific aspects of the aging process. Here, we aimed to investigate the influence of mtDNA variation on joint damage in a model of aging using conplastic mice. A ...

    • Oleate prevents palmitate-induced mitochondrial dysfunction in chondrocytes 

      Vázquez-Mosquera, María E.; Fernández-Moreno, Mercedes; Cortés-Pereira, Estefanía; Relaño, Sara; Dalmao-Fernández, Andrea; Ramos-Louro, Paula; Durán Sotuela, Alejandro; Rego-Pérez, Ignacio; Blanco García, Francisco J (Frontiers, 2021-06-15)
      [Abstract] The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors ...

    • Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication 

      Pernas, Berta; Rego-Pérez, Ignacio; Tabernilla, Andrés; Balboa-Barreiro, Vanesa; Relaño, Sara; Grandal, Marta; Crespo, Manuel; Mena, Álvaro; Castro-Iglesias, Ángeles; Blanco García, Francisco J; Poveda, Eva (Oxford, 2017-08-31)
      [Abstract] Objectives. To evaluate plasma mitochondrial DNA (mtDNA) levels among HIV-infected patients and its potential role as a biomarker of residual viral replication. Methods. HIV-infected patients on follow-up at a ...

    • Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis 

      Blanco García, Francisco J; Camacho Encina, María; González-Rodríguez, Lucía; Rego-Pérez, Ignacio; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Picchi, Florencia; Silva-Díaz, María T.; Herrero, Marta; Martínez, Helena; Verges, Josep; Ruiz-Romero, Cristina; Calamia, Valentina (Sage, 2019-08-24)
      [Abstract] Background: In the present study, we explored potential protein biomarkers useful to predict the therapeutic response of knee osteoarthritis (KOA) patients treated with pharmaceutical grade Chondroitin ...

    • PROCOAC (PROspective COhort of A Coruña) description: spanish prospective cohort to study osteoarthritis 

      Oreiro, Natividad; Raga, Ana C.; Rego-Pérez, Ignacio; Pértega-Díaz, Sonia; Silva-Díaz, Maite; Freire, Mercedes; Fernández-López, Carlos; Blanco García, Francisco J (Elsevier, 2021-05-03)
      [Abstract] Introduction and objective: The use of well characterized osteoarthritis (OA) cohorts is mandatory for the study and knowledge of this disease. Currently, there is no prospective cohort in this pathology in ...

    • Relationship between the dynamics of telomere loss in peripheral blood leukocytes from osteoarthritis patients and mitochondrial DNA haplogroup 

      Guillén, Rebeca; Otero, Fátima; Mosquera, Alejandro; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández García, José Luis (The Journal of Rheumatology Publishing, 2021-03-01)
      [Abstract] Objective: To evaluate the evolution of telomere length from peripheral blood leukocytes (PBLs) in subjects from the Osteoarthritis Initiative (OAI) cohort in relation to the incidence of osteoarthritis (OA), ...

    • Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers 

      Bonakdari, Hossein; Petellier, Jean-Pierre; Blanco García, Francisco J; Rego-Pérez, Ignacio; Durán-Sotuela, Alejandro; Aitken, Dawn; Jones, Graeme; Cicuttini, Flavia; Jamshidi, Afshin; Abram, François; Martel-Pelletier, Johanne (BioMed Central, 2022-09-12)
      [Abstract] Background. Knee osteoarthritis is the most prevalent chronic musculoskeletal debilitating disease. Current treatments are only symptomatic, and to improve this, we need a robust prediction model to stratify ...

    • Specific premature epigenetic aging of cartilage in osteoarthritis 

      Vidal-Bravo, Laura; López-Golán, Yolanda; Mera-Varela, Antonio; Rego-Pérez, Ignacio; Horvath, Steve; Zhang, Yuhua; Real, Álvaro del; Zhai, Guangju; Blanco García, Francisco J; Riancho, José A.; Gómez-Reino, Juan J.; González, Antonio (Impact Journals, 2016-09-28)
      [Abstract] Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, ...