Receptive field structure of burst and tonic firing in feline lateral geniculate nucleus
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Receptive field structure of burst and tonic firing in feline lateral geniculate nucleusData
2003-09-12Cita bibliográfica
Rivadulla C, Martínez L, Grieve KL, Cudeiro J. Receptive field structure of burst and tonic firing in feline lateral geniculate nucleus. J Physiol. 2003;553.2:601-610.
Resumo
There are two recognised modes of firing activity in thalamic cells, burst and tonic. A low-threshold (LT) burst (referred to from now on as ‘burst’) comprises a small number of high-frequency action potentials riding the peak of a LT Ca2+ spike which is preceded by a silent hyperpolarised state
>50 ms. This is traditionally viewed as a sleep-like phenomenon, with a shift to tonic mode at wakeup.
However, bursts have also been seen in the wake state and may be a significant feature for full activation of recipient cortical cells. Here we show that for visual stimulation of anaesthetised cats,
burst firing is restricted to a reduced area within the receptive field centre of lateral geniculate nucleus cells. Consistently, the receptive field size of all the recorded neurons decreased in size proportionally to the percentage of spikes in bursts versus tonic spikes, an effect that is further
demonstrated with pharmacological manipulation. The role of this shrinkage may be distinct from that also seen in sleep-like states and we suggest that this is a mechanism that trades spatial resolution for security of information transfer.
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This is the peer reviewed version of the following article which has been published in final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.
ISSN
0022-3751 (print)
1469-7793 (online)
1469-7793 (online)