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Biodistribution and Immunogenicity of Allogeneic Mesenchymal Stem Cells in a Rat Model of Intraarticular Chondrocyte Xenotransplantation
(Frontiers, 2017-11-06)
[Abstract] Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic ...
Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress
(BMC, 2017-06-12)
[Abstract] Background, Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this ...
Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication
(Oxford, 2017-08-31)
[Abstract] Objectives. To evaluate plasma mitochondrial DNA (mtDNA) levels among HIV-infected patients and its potential role as a biomarker of residual viral replication.
Methods. HIV-infected patients on follow-up at a ...
Cardiovascular disease in immune-mediated inflammatory diseases: a cross-sectional analysis of 6 cohorts
(Wolters Kluwer, 2017-06)
[Abstract] To analyze in several immune-mediated inflammatory diseases (IMIDs) the influence of demographic and clinical-related variables on the prevalence of cardiovascular disease (CVD), and compare their standardized ...
The role of osmolarity adjusting agents in the regulation of encapsulated cell behavior to provide a safer and more predictable delivery of therapeutics
(Taylor & Francis, 2017-10-27)
[Abstract] Transplantation of cells within alginate microspheres has been extensively studied for sustained drug delivery. However, the lack of control over cell behavior represents a major concern regarding the efficacy ...
CD105+-Mesenchymal Stem Cells Migrate into Osteoarthritis Joint: an Animal Model
(PLoS, 2017-11-30)
[Abstract] Mesenchymal stem cells are being the focus of connective tissue technology and regenerative medicine, presenting a good choice cell source for improving old and well recognized techniques of cartilage defect ...
Hif-1α knockdown reduces glycolytic metabolism and induces cell death of human synovial fibroblasts under normoxic conditions
(Nature, 2017-06-16)
[Abstract] Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O2 environments, elevated rates of glycolysis support critical cellular mechanisms ...
Discovery of circulating proteins associated to knee radiographic osteoarthritis
(Nature, 2017-03-09)
[Abstract] Currently there are no sufficiently sensitive biomarkers able to reflect changes in joint remodelling during osteoarthritis (OA). In this work, we took an affinity proteomic approach to profile serum samples for ...
Hydrogen sulfide and inflammatory joint diseases
(Bentham, 2017)
[Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...
The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint
(BioMed Central, 2017-06-06)
[Abstract]
Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ...