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Syncope in patients with transthyretin amyloid cardiomyopathy: clinical features and outcomes
(Taylor & Francis, 2022-03-23)
[Abstract] Background: We aimed to describe the clinical characteristics, underlying causes and outcomes of syncope in patients with transthyretin amyloid cardiomyopathy (ATTR-CM).
Methods: The clinical profile and ...
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure
(Massachusetts Medical Society, 2020-11-13)
[Abstract]
BACKGROUND.
The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction.
Its effect on cardiovascular ...
Impact of Donor-Recipient Age on Cardiac Transplant Survival. Subanalysis of the Spanish Heart Transplant Registry
(Elsevier, 2020-06-26)
[Abstract]
Introduction and objectives.
The age of heart transplant recipients and donors is progressively increasing. It is likely that not all donor-recipient age combinations have the same impact on mortality. The ...
Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: GALACTIC‐HF Baseline Characteristics and Comparison With Contemporary Clinical Trials
(Willey Online Library, 2020-09-20)
[Abstract]
Aims
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is being tested in the Global Approach ...
Determinants of Maximal Oxygen Uptake in Patients With Heart Failure
(Wiley Online Library, 2021-03-27)
[Abstract] Aims Maximum oxygen uptake (VO₂max) is an essential parameter to assess functional capacity of patients with heart failure (HF). We aimed to identify clinical factors that determine its value, as they have not ...
Impact of intrapatient blood level variability of calcineurin inhibitors on heart transplant outcomes
(Elsevier, 2021-03-18)
[Abstract]
Introduction and objectives.
Intrapatient blood level variability (IPV) of calcineurin inhibitors has been associated with poor outcomes in solid-organ transplant, but data for heart transplant are scarce. ...
Mitochondrial Pyruvate Carrier Abundance Mediates Pathological Cardiac Hypertrophy
(Springer Nature, 2020-10-26)
[Abstract]
Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates ...
Oxygen therapy and palliative care in patients with heart failure. Response
(Elsevier, 2020-05-04)
Malignancy following heart transplantation: differences in incidence and prognosis between sexes – a multicenter cohort study
(Wiley Online Library, 2021-01-22)
[Abstract]
Male patients are at increased risk for developing malignancy postheart transplantation (HT); however, real incidence and prognosis in both genders remain unknown. The aim of this study was to assess differences ...