Buscar
Mostrando ítems 111-120 de 193
Generating Rho-0 cells using mesenchymal stem cell lines
(PLoS, 2016-10-20)
[Abstract] Introduction, The generation of Rho-0 cells requires the use of an immortalization process, or tumor cell selection, followed by culture in the presence of ethidium bromide (EtBr), incurring the drawbacks its ...
Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study
(BioMed Central, 2014-09-27)
[Abstract] INTRODUCTION:
Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms ...
In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis
(Elsevier, 2018-08-25)
[Abstract] Selective cyclooxigenase (COX)-2 inhibitors were developed to prevent traditional non-steroidal anti-inflammatory drugs (tNSAIDs) gastro-intestinal adverse effects. VA692, a recently disclosed selective COX-2 ...
Analysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers
(American Society for Biochemistry and Molecular Biology (ASBMB), 2019-07-27)
[Abstract] Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human ...
Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes
(Wiley, 2019-02-12)
[Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage.
Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ...
Specific premature epigenetic aging of cartilage in osteoarthritis
(Impact Journals, 2016-09-28)
[Abstract] Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, ...
Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis
(BMC, 2015-09-04)
[Abstract] Introduction. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. ...
A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis
(Springer, 2016-10-04)
[Abstract] Background. Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is ...
Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis: data from the Osteoarthritis Initiative (OAI)
(PLoS, 2014-11-12)
[Abstract] OBJECTIVE:
To evaluate the influence of the mtDNA haplogroups on knee osteoarthritis progression in Osteoarthritis Initiative (OAI) participants through longitudinal data from radiographs and magnetic resonance ...
Long‐term safety, efficacy, and quality of life in patients with juvenile idiopathic arthritis treated with intravenous abatacept for up to seven years
(Wiley, 2015-06-19)
[Abstract] Objective. The efficacy and safety of abatacept in patients with juvenile idiopathic arthritis (JIA) who experienced an inadequate response to disease‐modifying antirheumatic drugs were previously established ...