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Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes
(Elsevier, 2014-07)
[Abstract] Objective. Hydrogen sulfide (H2S), the third gasotransmitter together with NO and CO, is emerging as a regulator of inflammation. To test if it might offer therapeutic value in the treatment of osteoarthritis ...
Translation of clinical problems in osteoarthritis into pathophysiological research goals
(BMJ, 2016-05-26)
[Abstract] Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent ...
Identificación de moléculas reguladoras del envejecimiento articular para el tratamiento de la artrosis
(2019)
[Resumo] Os fallos nos mecanismos de homeostase relacionados coa idade, como o defecto
de autofaxia e a acumulación de células senescentes, contribúen á dexeneración da
cartilaxe e á artrose (OA), para a cal no existen ...
OARSI Guidelines for the Non-Surgical Management of Knee, Hip, and Polyarticular Osteoarthritis
(Elsevier, 2019-11)
[Abstract] Objective: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular ...
Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
(BMJ, 2015-01-14)
[Abstract] Objectives. To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain.
Methods. Double-blind ...
The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis
(American Society for Biochemistry and Molecular Biology, 2017-09-01)
[Asbtract] Epidemiological findings support the hypothesis that type 2 diabetes mellitus (T2DM) is a risk factor for osteoarthritis (OA). Moreover, OA cartilage from patients with T2DM exhibits a greater response to ...
Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12
(Wiley, 2019-03-22)
[Abstract] Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expression in homeostasis, together with their ...
Clinical profile, level of affection and therapeutic management of patients with osteoarthritis in primary care: the spanish multicenter study EVALÚA
(Elsevier, 2015-04-16)
[Abstract] Objective. To determine the clinical profile, degree of involvement and management in patients with knee, hip or hand osteoarthritis.
Methods. Observational study (health centres from 14 autonomous regions, n ...
Leukocyte telomere length in patients with radiographic knee osteoarthritis
(Wiley, 2019-11-29)
[Abstract] Relative mean telomere sequence amount was determined by quantitative PCR (qPCR) of peripheral blood leukocyte (PBL) samples obtained at recruitment (n = 310) from individuals from the Osteoarthritis (OA) ...
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
(Nature Publishing Group, 2018-12-05)
[Abstract] Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and ...