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Practical guidelines for diagnosis and treatment of acromegaly
(Elsevier, 2013-10)
[Abstract] Acromegaly and gigantism are due to excess GH secretion, usually by a pituitary adenoma. It is an uncommon disease.
Diagnosis is made by showing elevated GH and IGF-I levels in patients with a clinical picture ...
Ghrelin in obesity, physiological and pharmacological considerations
(Bentham, 2013-04)
[Abstract] The aim of this review is to summarize the physiological and pharmacological aspects of ghrelin. Obesity can be defined as an excess of body fat and is associated with significant disturbances in metabolic and ...
Place of preoperative treatment of acromegaly with somatostatin analog on surgical outcome: a systematic review and meta-analysis
(PLoS ONE, 2013-04-25)
[Abstract] Context. Transsphenoidal neurosurgery is the accepted first-line treatment of acromegaly in the majority of patients. Previous studies addressing preoperative somatostatin analog (SSA) treatment and subsequent ...
Efficacy of glutamine in the prevention of acute radiation enteritis: a randomized controlled trial
(SAGE, 2013-03-07)
[Abstract] Background: Acute radiation enteritis is a common adverse effect related to radiotherapy (RT). Glutamine is an immune modulator and antioxidant amino acid that can exert a protective role in patients receiving ...
Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
(Endocrine Society, 2013)
[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ...
Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism
(Endocrine Society, 2013-01-21)
[Abstract] Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially of the let-7 family, with putative functions in early (embryo) development. ...