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Mostrando ítems 11-20 de 42
Mitochondrial genetics and epigenetics in osteoarthritis
(Frontiers, 2020-01-17)
[Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ...
Are Musculoskeletal Conditions Neglected in National Health Surveys?
(Oxford University Press, 2021-01-26)
[Abstract] Objective: To describe the proportion of national health surveys that contain questions on the prevalence and consequences of musculoskeletal conditions.
Methods: We used a comprehensive search strategy to ...
Mesenchymal Stromal Cells for Articular Cartilage Repair: Preclinical Studies
(AO Research Institute Davos (ARI), 2020-08-26)
[Abstract]
Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the
population aging and the lack of curative solutions. An effective cell therapy may be the best treatment ...
Impaired metabolic flexibility in the osteoarthritis process: a study on transmitochondrial cybrids
(MDPI, 2020-03-27)
[Abstract] Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular energy demand, but studies implicate impaired ...
Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis
(Elsevier, 2020-05-14)
[Abstract] Mitochondrial dysfunction of human articular chondrocytes is considered a hallmark of cartilage degradation and OA pathogenesis. Due to the huge number of cellular processes in which mitochondria is implicated, ...
Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction
(Frontiers Media S.A., 2020-10-14)
[Abstract]
Osteoarthritis (OA) is the most common musculoskeletal disorder. Although joint
replacement remains the standard of care for knee OA patients, knee joint distraction
(KJD), which works by temporarily off-loading ...
One-year, efficacy and safety open label study, with a single injection of a new hyaluronan for knee OA: the SOYA trial
(DovePress, 2021-07-21)
[Abstract] Purpose. To assess the efficacy and safety of a single injection of a new formulation of hyaluronic acid (MPS-HA2%) in patients with symptomatic knee osteoarthritis after 12 months’ follow-up.
Patients and ...
Prevalence of Symptomatic Axial Osteoarthritis Phenotypes in Spain and Associated Socio-Demographic, Anthropometric, and Lifestyle Variables
(Springer, 2021-11-10)
[Abstract] Objective. Axial osteoarthritis (OA) is a common cause of back and neck pain, however, few studies have examined its prevalence. The aim was to estimate the prevalence and the characteristics of symptomatic axial ...
Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis
(MDPI, 2021-06-16)
[Abstract] Osteoarthritis (OA) is the most common musculoskeletal disorder causing a great disability and a reduction in the quality of life. In OA, articular chondrocytes (AC) and synovial fibroblasts (SF) release ...
Targeted Phospholipidomic Analysis of Synovial Fluid as a Tool for Osteoarthritis Deep Phenotyping
(Elsevier, 2021-10-20)
[Abstract] Objective. The aim of this study was to carry out a targeted phospholipidomic analysis on synovial fluid (SF) from patients with different grades of osteoarthritis (OA) and controls, in order to search for ...