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Innovative three-step microwave-promoted synthesis of N-propargyltetrahydroquinoline and 1,2,3-triazole derivatives as a potential factor Xa (FXa) inhibitors: drug design, synthesis, and biological evaluation
(MDPI AG, 2020-01-23)
[Abstract]: The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble fibrin that terminates in production of a clot. Factor Xa (FXa) is a serine protease involved in the blood coagulation ...
RNA-Seq analysis for assessing the early response to DSP toxins in Mytilus galloprovincialis digestive gland and gill
(MDPI, 2018-10-16)
[Abstract] The harmful effects of diarrhetic shellfish poisoning (DSP) toxins on mammalian cell lines have been widely assessed. Studies in bivalves suggest that mussels display a resistance to the cytogenotoxic effects ...
A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity Against Colorectal and Triple Negative Breast Cancer Cells
(MDPI, 2020-03-30)
[Abstract] A family of compounds with the general formula [Fe(η5-C5H5)(CO)(PPh3)(NCR)]+ has been synthesized (NCR = benzonitrile (1); 4-hydroxybenzonitrile (2); 4-hydroxymethylbenzonitrile (3); 4-aminobenzonitrile (4); ...
The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis
Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. ...
Design and Development of Small-Molecule Arylaldoxime/5-Nitroimidazole Hybrids as Potent Inhibitors of MARK4: a Promising Approach for Target-Based Cancer Therapy
(American Chemical Society, 2020-09-01)
[Abstract] Microtubule affinity-regulating kinase 4 (MARK4), a member of the serine/threonine kinase family, is an emerging therapeutic target in anticancer drug discovery paradigm due to its involvement in regulation of ...
Genetic characterization of wild, broodstock and seed samples of "Polititapes rhomboides" (Bivalvia: Veneridae): implications for hatchery seed production
(Elsevier, 2021-03-13)
[Abstract] The banded carpet shell Polititapes rhomboides is a fishery resource and a suitable candidate for the development of native clam aquaculture in Europe. Here, we analyzed nine microsatellite loci in wild samples ...
Genetic Variability in Ruditapes Decussatus Clam Combined With Perkinsus Infection Level to Support Founder Population Selection for a Breeding Program
(PeerJ, 2020-10-28)
[Abstract] Clam farmers worldwide face several challenges, including irregular seed supply and high mortalities due to pathogenic organisms such as "Perkinsus olseni". In Europe, there is a high unmet consumer demand for ...
26,26,26,27,27,27-Hexadeuterated-1,25-Dihydroxyvitamin D3 (1,25D-d6) As Adjuvant of Chemotherapy in Breast Cancer Cell Lines
It has been demonstrated that 1,25-dihydroxyvitamin D3 (1,25D) and some of its analogues have antitumor activity. 1,25D labeled with deuterium (26,26,26,27,27,27-hexadeuterated 1a,25-dihydroxyvitamin D3, or 1,25D-d6) is ...