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The multispecies microbial cluster of Fusobacterium, Parvimonas, Bacteroides and Faecalibacterium as a precision biomarker for colorectal cancer diagnosis
dc.contributor.author | Ladra, Susana | |
dc.contributor.author | Poza, Margarita | |
dc.contributor.author | Conde-Pérez, Kelly | |
dc.contributor.author | Aja-Macaya, Pablo | |
dc.contributor.author | Buetas, Elena | |
dc.contributor.author | Trigo-Tasende, Noelia | |
dc.contributor.author | Nasser-Ali, Mohammed | |
dc.contributor.author | Rumbo-Feal, Soraya | |
dc.contributor.author | Nión Cabeza, Paula | |
dc.contributor.author | Martin-De Arribas, E. | |
dc.contributor.author | Estévez, Lara | |
dc.contributor.author | Otero Alén, Begoña | |
dc.contributor.author | Noguera, José Francisco | |
dc.contributor.author | Concha, Ángel | |
dc.contributor.author | Pardiñas López, Simón | |
dc.contributor.author | Carda-Diéguez, Miguel | |
dc.contributor.author | Gómez-Randulfe Rodríguez, Martín Igor | |
dc.contributor.author | Martinez-Lago, Nieves | |
dc.contributor.author | Aparicio, Luis A. | |
dc.contributor.author | Bou, Germán | |
dc.contributor.author | Mira, Alex | |
dc.contributor.author | Vallejo, J.A. | |
dc.date.accessioned | 2024-09-03T16:19:08Z | |
dc.date.available | 2024-09-03T16:19:08Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Conde-Pérez, K., Aja-Macaya, P., Buetas, E., Trigo-Tasende, N., Nasser-Ali, M., Rumbo-Feal, S., Nión, P., Arribas, E. M.-D., Estévez, L. S., Otero-Alén, B., Noguera, J. F., Concha, Á., Pardiñas-López, S., Carda-Diéguez, M., Gómez-Randulfe, I., Martínez-Lago, N., Ladra, S., Aparicio, L. M. A., Bou, G., et al. (2024). The multispecies microbial cluster of Fusobacterium, Parvimonas, Bacteroides and Faecalibacterium as a precision biomarker for colorectal cancer diagnosis. Molecular Oncology, 18(5), 1093-1122. https://doi.org/10.1002/1878-0261.13604 | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/38831 | |
dc.description.abstract | [Abstract] The incidence of colorectal cancer (CRC) has increased worldwide, and early diagnosis is crucial to reduce mortality rates. Therefore, new noninvasive biomarkers for CRC are required. Recent studies have revealed an imbalance in the oral and gut microbiomes of patients with CRC, as well as impaired gut vascular barrier function. In the present study, the microbiomes of saliva, crevicular fluid, feces, and non-neoplastic and tumor intestinal tissue samples of 93 CRC patients and 30 healthy individuals without digestive disorders (non-CRC) were analyzed by 16S rRNA metabarcoding procedures. The data revealed that Parvimonas, Fusobacterium, and Bacteroides fragilis were significantly over-represented in stool samples of CRC patients, whereas Faecalibacterium and Blautia were significantly over-abundant in the non-CRC group. Moreover, the tumor samples were enriched in well-known periodontal anaerobes, including Fusobacterium, Parvimonas, Peptostreptococcus, Porphyromonas, and Prevotella. Co-occurrence patterns of these oral microorganisms were observed in the subgingival pocket and in the tumor tissues of CRC patients, where they also correlated with other gut microbes, such as Hungatella. This study provides new evidence that oral pathobionts, normally located in subgingival pockets, can migrate to the colon and probably aggregate with aerobic bacteria, forming synergistic consortia. Furthermore, we suggest that the group composed of Fusobacterium, Parvimonas, Bacteroides, and Faecalibacterium could be used to design an excellent noninvasive fecal test for the early diagnosis of CRC. The combination of these four genera would significantly improve the reliability of a discriminatory test with respect to others that use a single species as a unique CRC biomarker. | es_ES |
dc.description.sponsorship | The authors want to appreciate the good disposition of all the CRC patients for collaborating with us. We would like to thank Gema Carro Díaz and Montserrat Ingelmo Sánchez for their assistance during patients' recruitment time and also during tissue sample collection. This work would not be possible without the support of professionals from the Microbiology, Surgery, Pathology and Oncology Services and Biobank of CHUAC (Spain). The present study received funding from the Instituto de Salud Carlos III (ISCIII), Spain, through the project PI20/00413, cofunded by the European Union (EU) to MP. The whole work has been also supported by the project RTI2018-102032-B-I00 from the Spanish Ministry of Science and Innovation to AM and by CIBER INFEC ISCIII (CB21/13/00055) to GB and MP Biobank of A Coruña was supported by ISCIII-Fondos FEDER (EU) by grant PT20/00128. KC-P was financially supported by the Spanish Association against Cancer (AECC). EB was supported by a grant from the Spanish Ministry of Science and Innovation PRE2019-088126. SL and EM-DA were supported by grants from GAIN (Xunta de Galicia, Spain) with references ED431C 2021/53 and ED431G 2019/01. | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C 2021/53 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431G 2019/01 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CB21%2F13%2F00055/ES/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PT20%2F00128/ES/Plataformas ISCIII de apoyo a la I+D+I en Biomedicina y Ciencias de la Salud: Plataforma de Biobanco y Organoides | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PRE2019-088126/ES/EFECTOS LOCALES Y SISTEMICOS DE LA MICROBIOTA ORAL | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-102032-B-I00/ES/EFECTOS LOCALES Y SISTEMICOS DE LA MICROBIOTA ORAL | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00413/ES/FARMACOMICROBIOMICA Y MEDICINA PERSONALIZADA EN LA TERAPIA DEL CANCER COLORECTAL/ | es_ES |
dc.relation.uri | https://doi.org/10.1002/1878-0261.13604 | es_ES |
dc.rights | Creative Commons Attribution License CC-BY | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Bacterial consortium | es_ES |
dc.subject | Biomarkers | es_ES |
dc.subject | Colorectalcance | es_ES |
dc.subject | Microbiome | es_ES |
dc.subject | Oral-gut axis | es_ES |
dc.subject | Periodontal disease | es_ES |
dc.title | The multispecies microbial cluster of Fusobacterium, Parvimonas, Bacteroides and Faecalibacterium as a precision biomarker for colorectal cancer diagnosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Molecular Oncology | es_ES |
UDC.volume | 18 | es_ES |
UDC.issue | 5 | es_ES |
UDC.startPage | 1093 | es_ES |
UDC.endPage | 1122 | es_ES |
dc.identifier.doi | 10.1002/1878-0261.13604 |
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