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A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain
dc.contributor.author | Iglesias, Pablo | |
dc.contributor.author | Penas, Cristina | |
dc.contributor.author | Barral-Cagiao, Laura | |
dc.contributor.author | Pazos, Elena | |
dc.contributor.author | Costoya, Jose A. | |
dc.date.accessioned | 2024-07-01T07:39:40Z | |
dc.date.available | 2024-07-01T07:39:40Z | |
dc.date.issued | 2019-05-08 | |
dc.identifier.citation | Iglesias, P., Penas, C., Barral-Cagiao, L., Pazos, E. & Costoya, J. A. A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain. Sci Rep 9, 7117 (2019). | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/2183/37565 | |
dc.description.abstract | [Abstract] Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. One of the characteristic features of some tumour types is that their fast growth leads to deficient intratumoral vascularization, which results in low oxygen availability. To overcome this lack of oxygen, tumoural cells activate the neoangiogenic program by upregulating the transcription factor HIF-1α. Herein we report a non-invasive in vitro detection method of hypoxia using designed fluorescent peptide probes based on the oxygen-dependent degradation domain of HIF-1α. The fluorescent probe retains the oxygen-sensing capability of HIF-1α, so that it is stabilized under hypoxia and readily degraded by the proteasome under normoxia, thus providing direct information of the cellular oxygen availability. | es_ES |
dc.description.sponsorship | We thank the members of MOL Laboratory for helpful discussions and critiques of this work. This work has received financial support from the Spanish MICINN (SAF2009-08629; J.A.C.) and ISCIII, MINECO (PI15/01129), AEI/FEDER, UE (CTQ2017-89166-R; E.P.), the Consellería de Cultura, Educación e Ordenación Universitaria (GPC2014/030, INCITE08PXIB208091PR; J.A.C.), the Xunta de Galicia (Centro Singular de Investigación de Galicia accreditations 2016‐2019, ED431G/05 and ED431G/09) and the European Regional Development Fund (ERDF). C.P. thanks the Spanish MICINN for her PhD fellowship. E.P. thanks the UDC-Inditex InTalent Programme for her research contract and funding | es_ES |
dc.description.sponsorship | Xunta de Galicia; GPC2014/030 | es_ES |
dc.description.sponsorship | Xunta de Galicia; INCITE08PXIB208091PR | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431G/05 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431G/09 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/Plan Nacional de I+D+i 2008-2011/SAF2009-08629/ES/Caracterizacion Molecular De Los Mecanismos Implicados En La Transicion De Gliomas De Bajo A Alto Grado | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PI15%2F01129/ES/Metabolismo de las células tumorales y AMPK. Talón de Aquiles y nueva diana terapéutica en los astrocitomas cerebrales | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-89166-R/ES/HERRAMIENTAS PEPTIDICAS PARA APLICACIONES BIOLOGICAS: SENSORES INTELIGENTES PARA ESTUDIAR NITRACION DE PROTEINAS Y NANOMATERIALES CON FUNCIONALIDADES MODULABLES | es_ES |
dc.relation.uri | https://doi.org/10.1038/s41598-019-43618-4 | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.title | A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Scientific Reports | es_ES |
UDC.volume | 9 | es_ES |
UDC.startPage | 7117 | es_ES |
dc.identifier.doi | 10.1038/s41598-019-43618-4 |
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