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Association of high serum levels of growth factors with good outcome in ischemic stroke: a multicenter study
dc.contributor.author | Sobrino, Tomás | |
dc.contributor.author | Rodríguez-Yáñez, Manuel | |
dc.contributor.author | Campos, Francisco | |
dc.contributor.author | Iglesias-Rey, Ramón | |
dc.contributor.author | Millán, Mónica | |
dc.contributor.author | Pérez de la Osa, Natalia | |
dc.contributor.author | Dávalos, Antonio | |
dc.contributor.author | Delgado-Mederos, Raquel | |
dc.contributor.author | Martínez-Domeño, Alejandro | |
dc.contributor.author | Martí-Fábregas, Joan | |
dc.contributor.author | Castellanos, María del Mar | |
dc.contributor.author | Serena, Joaquín | |
dc.contributor.author | Lago, Aida | |
dc.contributor.author | Díez-Tejedor, Exuperio | |
dc.contributor.author | Castillo, José | |
dc.date.accessioned | 2024-06-21T07:04:35Z | |
dc.date.available | 2024-06-21T07:04:35Z | |
dc.date.issued | 2019-11-25 | |
dc.identifier.citation | Sobrino T, Rodríguez-Yáñez M, Campos F, Iglesias-Rey R, Millán M, de la Ossa NP, Dávalos A, Delgado-Mederos R, Martínez-Domeño A, Martí-Fábregas J, Castellanos M, Serena J, Lago A, Díez-Tejedor E, Castillo J. Association of high serum levels of growth factors with good outcome in ischemic stroke: a multicenter study . Transl Stroke Res. 2020 Aug;11(4):653-663. | es_ES |
dc.identifier.issn | 1868-4483 | |
dc.identifier.uri | http://hdl.handle.net/2183/37245 | |
dc.description | Observational study | es_ES |
dc.description.abstract | [Abstract] The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62.1%; mean age, 68.2 ± 11.4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] ≤ 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 ± 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1α were measured by ELISA at admission, 7 ± 1 days, at 3 ± 1 months, and 12 ± 3 months. Except for BDNF, all GF and SDF-1α serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0.01). High serum levels at day 7 of VEGF (OR, 19.3), Ang-1 (OR, 14.7), G-CSF (OR, 9.6), and SDF-1α (OR, 28.5) were independently associated with good outcome at 12 months (all p < 0.0001). On the other hand, serum levels of VEGF (B, - 21.4), G-CSF (B, - 14.0), Ang-1 (B, - 13.3), and SDF-1α (B, - 44.6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0.01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1α at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up. | es_ES |
dc.description.sponsorship | This project was partially supported by grants from the Spanish Ministry of Economy and Competitiveness (SAF2014-56336-R; RTI2018-102165-B-I00 and SAF2017-84267-R), Xunta de Galicia (Consellería Educación: GRC2014/027 and IN607A2018/3), Instituto de Salud Carlos III (PI13/00292, PI14/01879 and PI17/01103), Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS PLUS (RD16/0019), and by the European Union FEDER program. T. Sobrino (CP12/03121 &CPII17/00027) and F. Campos (CP14/00154 & CPII19/00020) are recipients of research contracts from Miguel Servet Program of Instituto de Salud Carlos III. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/SAF2014-56336-R/ES/NANONEUROPROTECCION TERMO-MOLECULAR VECTORIZADA EN LA ISQUEMIA CEREBRAL | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/RTI2018-102165-B-I00/ES/ESTUDIO TRASLACIONAL DE LA DISFUNCION ENDOTELIAL COMO FACTOR CLAVE DE LA ETIOPATOGENESIS DE LA ENFERMEDAD DE ALZHEIMER: DEL LABORATORIO A LA CLINICA | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/SAF2017-84267-R/ES/NANOSONDAS DIAPEUTICAS AVANZADAS PARA IMAGENES MOLECULARES: EVALUACION DE LA DISFUNCION ENDOTELIAL EN LA ISQUEMIA CEREBRAL | es_ES |
dc.description.sponsorship | Xunta de Galicia; GRC2014/027 | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN607A2018/3 | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI13%2F00292/ES/Encapsulación del activador del plasminógeno tisular (tPA) en nanoestructuras vectorizadas y eco-sensibles | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI14%2F01879/ES/Reprogramación in vivo del cerebro isquémico como nueva opción terapéutica en el infarto cerebral | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17%2F01103/ES/TROMBOIMAGEN MOLECULAR POR RESONANCIA MAGNETICA CON NANOPARTICULAS DUALES VECTORIZADAS. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RD16%2F0019%2F0015/ES/Red de Enfermedades Vasculares Cerebrales. INVICTUS PLUS | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Acción Estratégica de Salud/CP12%2F03121/ES/ | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; CPII17/00027 | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/CP14%2F00154/ES/ | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III; CPII19/00020 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation.uri | https://doi.org/10.1007/s12975-019-00747-2 | es_ES |
dc.rights | Creative Commons Attribution 4.0 International License (CC-BY 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Growth factors | es_ES |
dc.subject | Infarct volume | es_ES |
dc.subject | Ischemic stroke | es_ES |
dc.subject | Prognosis | es_ES |
dc.title | Association of high serum levels of growth factors with good outcome in ischemic stroke: a multicenter study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Traslational Stroke Research | es_ES |
UDC.volume | 11 | es_ES |
UDC.startPage | 653 | es_ES |
UDC.endPage | 663 | es_ES |
dc.identifier.doi | 10.1007/s12975-019-00747-2 |
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