Mostrar o rexistro simple do ítem
The Effect of HMGB1 and HMGB2 on Transcriptional Regulation Differs in Neuroendocrine and Adenocarcinoma Models of Prostate Cancer
dc.contributor.author | Salamini-Montemurri, Martín | |
dc.contributor.author | Vizoso-Vázquez, Ángel | |
dc.contributor.author | Barreiro-Alonso, Aida | |
dc.contributor.author | Lorenzo-Catoira, Lidia | |
dc.contributor.author | Rodríguez-Belmonte, Esther | |
dc.contributor.author | Cerdán, María Esperanza | |
dc.contributor.author | Lamas, Mónica | |
dc.date.accessioned | 2024-06-20T17:18:53Z | |
dc.date.available | 2024-06-20T17:18:53Z | |
dc.date.issued | 2024-03-07 | |
dc.identifier.citation | Salamini-Montemurri, M.; Vizoso-Vázquez, Á.; Barreiro-Alonso, A.; Lorenzo-Catoira, L.; Rodríguez-Belmonte, E.; Cerdán, M.-E.; Lamas-Maceiras, M. The Effect of HMGB1 and HMGB2 on Transcriptional Regulation Differs in Neuroendocrine and Adenocarcinoma Models of Prostate Cancer. Int. J. Mol. Sci. 2024, 25, 3106. https://doi.org/10.3390/ijms25063106 | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/2183/37241 | |
dc.description | This article belongs to the Special Issue Recent Molecular Biology on Ovarian Cancer and Prostate Cancer | es_ES |
dc.description.abstract | [Abstract] Human high-mobility group-B (HMGB) proteins regulate gene expression in prostate cancer (PCa), a leading cause of oncological death in men. Their role in aggressive PCa cancers, which do not respond to hormonal treatment, was analyzed. The effects of HMGB1 and HMGB2 silencing upon the expression of genes previously related to PCa were studied in the PCa cell line PC-3 (selected as a small cell neuroendocrine carcinoma, SCNC, PCa model not responding to hormonal treatment). A total of 72% of genes analyzed, using pre-designed primer panels, were affected. HMGB1 behaved mostly as a repressor, but HMGB2 as an activator. Changes in SERPINE1, CDK1, ZWINT, and FN1 expression were validated using qRT-PCR after HMGB1 silencing or overexpression in PC-3 and LNCaP (selected as an adenocarcinoma model of PCa responding to hormonal treatment) cell lines. Similarly, the regulatory role of HMGB2 upon SERPINE1, ZWINT, FN1, IGFPB3, and TYMS expression was validated, finding differences between cell lines. The correlation between the expression of HMGB1, HMGB2, and their targets was analyzed in PCa patient samples and also in PCa subgroups, classified as neuroendocrine positive or negative, in public databases. These results allow a better understanding of the role of HMGB proteins in PCa and contribute to find specific biomarkers for aggressive PCa. | es_ES |
dc.description.sponsorship | This research was funded by the Plan Estatal I + D + i, Instituto de Salud Carlos III (ISCIII, Spain, grant no. PI18/01417 and Fortalece FORT23/00010) and the Ministerio de Ciencia e Innovación (grant no. PID2021-124564OB-I00), and co-funded by the Fondo Europeo de Desarrollo Regional-FEDER (The European Regional Development Fund-ERDF) “A way of Making Europe” and by the Xunta de Galicia (Consolidación Grupos Referencia Competitiva, grant no. ED431C 2020-08). M.S.-M. acknowledges the Ministry of Science, Innovation, and Universities of Spain for funding through an FPU fellowship | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C 2020-08 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI18%2F01714/ES/Búsqueda de interacciones HMGB-IncRNAs útiles en diagnóstico cáncer de ovario/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124564OB-I00/ES/INMUNOINTERACTOMA DE RECEPTORES LINFOCITICOS Y PEQUEÑOS PEPTIDOS DERIVADOS DE LNCRNAS ESPECIFICOS DE CANCER DE OVARIO/ | es_ES |
dc.relation.uri | https://doi.org/10.3390/ijms25063106 | es_ES |
dc.rights | Atribución 4.0 Internacional | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | HMGB proteins | es_ES |
dc.subject | SERPINE1 | es_ES |
dc.subject | ZWINT | es_ES |
dc.subject | FN1 | es_ES |
dc.subject | IGBPB3 | es_ES |
dc.subject | TYMS | es_ES |
dc.subject | CDK1 | es_ES |
dc.subject | Neuroendocrine prostatic cancer | es_ES |
dc.subject | Transcriptional regulation | es_ES |
dc.title | The Effect of HMGB1 and HMGB2 on Transcriptional Regulation Differs in Neuroendocrine and Adenocarcinoma Models of Prostate Cancer | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | International Journal of Molecular Sciences | es_ES |
UDC.volume | 25 (2024) | es_ES |
UDC.issue | 6 | es_ES |
UDC.startPage | 3106 | es_ES |
dc.identifier.doi | 10.3390/ijms25063106 |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
GI-EXPRELA - Artigos [28]